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Synfacts 2007(1): 0094-0094  
DOI: 10.1055/s-2006-955667
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York

Chiral Chromenes via Domino Oxa-Michael-Aldol Reaction

Contributor(s): Benjamin List, Michael Stadler
H. Li, J. Wang, T. E-Nunu, L. Zu, W. Jiang, S. Wei*, W. Wang*
University of New Mexico, Albuquerque, USA and Nanjing Normal University, P. R. of China
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Publication History

Publication Date:
15 December 2006 (online)

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Significance

A one-pot reaction affording chiral chromenes is presented. It proceeds via a domino oxa-Michael-aldol reaction sequence between α,β-unsaturated aldehydes and salicylaldehydes and is promoted by diphenylpyrrolinol triethylsilyl ether. Good to excellent yields and enantioselectivities have been achieved.