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Pharmacopsychiatry 2006; 39(6): 229
DOI: 10.1055/s-2006-951384
Letter

© Georg Thieme Verlag KG Stuttgart · New York

Bupropion in Atopic Dermatitis

E. González 1 , R. M. Sanguino 2 , M. A. Franco 3
  • 1Complejo Hospitalario San Luis, Palencia, Spain
  • 2Unidad Salud Mental, Palencia, Spain
  • 3Complejo Asistencial, Zamora, Spain
Further Information

Publication History

Received 9. 1. 2006 Revised 13. 3. 2006

Accepted 5. 7. 2006

Publication Date:
23 November 2006 (online)

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Bupropion is an antidepressive drug whose main mechanism of action seems to be the inhibition of noradrenaline and dopamine recapture. We present a clinical case of a 50-year-old person with severe atopic dermatitis (A.D.) and without psychiatric symptoms associated, who was casually treated with bupropion with very good results. The mechanisms of action are not yet known, given the diversity of the implied physiopathology mechanisms: genetic, immunological, inflammatory, etc. The use of bupropion in serious and resistant cases to other treatments could constitute a pertinent therapeutic alternative.

References

  • 1 Altschuler EL, Kast E. Bupropion in psoriasis and atopic dermatitis: decreased tumor necrosis factor-alfa?.  Psychosom Med. 2003;  65 719
    CrossrefPubMedGoogle Scholar
  • 2 Drake LA, Fallon JD, Sober A. Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream.  J Am Acad Dermatol. 1994;  31 613-616
    PubMedGoogle Scholar
  • 3 Ehlers A, Stangier U, Gieler U. Treatment of atopic dermatitis: a comparison of psychological and dermatological approaches to relapse prevention.  J Consult Clin Psychol. 1995;  63 624
    PubMedGoogle Scholar
  • 4 Hardman R, Hopkins EJ, Pye AM, Solomon M, Solomon S. A trial of imipramine in the treatment of psoriasis.  J Coll Gen Pract. 1965;  10 315-316
    PubMedGoogle Scholar
  • 5 Lesley MA. Psychocutaneous disorders. In: Sadock BJ, Sadock VA. Kaplan & Sadok's Comprehensive Textbook of Psychiatry,. Volume 2 Lippincott Willians & Wilkins: Philadelphia 2005: 2164-2173
    Google Scholar
  • 6 Modell JG, Boyce S, Taylor E, Katholi C. Treatment of atopic dermatitis and psoriasis vulgaris with bupropion-SR: a pilot study.  Psychosom Med. 2002;  64 835-840
    CrossrefPubMedGoogle Scholar
  • 7 Rush AJ, Hudziak J, Rettew DC. Bupropion. In: Sadock BJ, Sadock VA. Kaplan & Sadok's Comprehensive Textbook of Psychiatry,. Volume 2 Lippincott Willians & Wilkins: Philadelphia 2005: 2791-2797
    Google Scholar
  • 8 Ugarte L, Goinetxea B, Sánchez N, Pikaza U. Bupropión. En: Salazar M, Peralta C, Pastor J. Tratado de Psicofarmacología: bases y aplicación clínica. Madrid: Editorial Médica Panamericana 2005: 474-478
    Google Scholar

Correspondence

Emilio González PablosM.D. 

Complejo Hospitalario San Luis

Carretera de Burgos s/n.

34004 Palencia

Spain

Phone: +34/979/16 53 24

Fax: +34/979/16 54 43

Email: ch@sanluis.org

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