Synthesis of Harounoside, A Naturally Occurring Pentalongin Hydroquinone Bisglucoside

Tuyen Nguyen Van; Sven Claessens; Pascal Habonimana; Kourosch Abbaspour Tehrani; Luc Van Puyvelde; Norbert De Kimpe

doi:10.1055/s-2006-950437

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Synlett 2006(15): 2469-2471
DOI: 10.1055/s-2006-950437

LETTER

Synthesis of Harounoside, A Naturally Occurring Pentalongin Hydroquinone Bisglucoside

Tuyen Nguyen Van^a, Sven Claessens^a, Pascal Habonimana^a, Kourosch Abbaspour Tehrani^b, Luc Van Puyvelde^a, Norbert De Kimpe*^a
^a Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
^b Department of Organic Chemistry, Faculty of Science, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
Fax: +32(9)2646243; e-Mail: norbert.dekimpe@UGent.be;

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Publication History

Received 29 June 2006
Publication Date:
08 September 2006 (online)

Abstract
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Abstract

The recently isolated natural product harounoside, namely 5,10-dihydroxy-2H-naphtho[2,3-c]pyran-β-d-bisglucopyranoside, was conveniently synthesized for the first time from pentalongin in 84% yield over three steps.

Key words

natural products - total synthesis - glucosidation

References

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