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Planta Med 2006; 72(13): 1235-1238
DOI: 10.1055/s-2006-947192
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Compounds of Schizolaena hystrix from the Madagascar Rainforest

Brian T. Murphy1 , Shugeng Cao1 , Andrew Norris1 , James S. Miller2 , Fidisoa Ratovoson3 , Rabodo Andriantsiferana4 , Vincent E. Rasamison4 , David G. I. Kingston1
  • 1Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
  • 2Missouri Botanical Garden, St. Louis, Missouri, USA
  • 3Missouri Botanical Garden, Antananarivo, Madagascar
  • 4Centre National d’Application des Recherches Pharmaceutiques, Antananarivo, Madagascar
Further Information

Publication History

Received: May 4, 2006

Accepted: June 1, 2006

Publication Date:
10 August 2006 (online)

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Abstract

Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of Schizolaena hystrix afforded the two new long-chain compounds, 3S-acetoxyeicosanoic acid ethyl ester (1) and 3S-acetoxydoeicosanoic acid (2), and the known long-chain compound 3S-acetoxyeicosanoic acid (3). In addition, the long-chain alcohol 1-hydroxydodecan-2-one (7), as well as the new flavonoid schizolaenone C (4) and the two known flavonoids diplacol (5) and 3′-prenylnaringenin (6) were isolated from a methanol extract of the same plant. Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported.

References

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Prof. Dr. David G. I. Kingston

Department of Chemistry

M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

Virginia 24061

USA

Phone: +1-540-231-6570

Fax: +1-540-231-3255

Email: dkingston@vt.edu

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