Fortschr Neurol Psychiatr 2007; 75(2): 107-122
DOI: 10.1055/s-2006-944313
Fort- und Weiterbildung
© Georg Thieme Verlag Stuttgart · New York

Intrazerebrale Blutungen

Intracerebral HaemorrhageH.-C.  Koennecke1 , A.  Kauert1
  • 1Abteilung für Neurologie, Ev. Krankenhaus Königin Elisabeth Herzberge
Further Information

Publication History

Publication Date:
13 March 2008 (online)

1. Klassifikation

Intrazerebrale Blutungen (ICB) sind intraparenchymatöse Blutungen des Gehirns als Folge einer Störung der vaskulären Integrität zerebraler Gefäße. Entsprechend der Lokalisation können lobäre Blutungen (parietal, temporal, frontal, okzipital), Stammganglienblutungen (Putamen bzw. Nucl. lentiformis, Caudatum, Thalamus), Hirnstammblutungen (Pons, Mesenzephalon, Medulla oblongata) und zerebelläre Blutungen (Kleinhirnwurm, Kleinhirnhemisphäre) differenziert werden. Folgt man den Ursachen der Blutung, unterscheidet man primäre von sekundären, so genannten symptomatischen Blutungen. Primäre Blutungen sind hypertensiv oder durch eine zerebrale Amyloidangiopathie (CAA) bedingt. Ursachen für die im Vergleich selteneren symptomatischen ICB können z. B. Gerinnungsstörungen, ein Schädel-Hirn-Trauma oder eine Gefäßmalformation sein. Eine Auflistung verschiedener Ursachen sekundärer ICB zeigt [Tab. 1]. Besonders bei ventrikelnahen Blutungen kann es zum Einbruch der Blutung in das Ventrikelsystem kommen. Eine Sonderform stellt die sogenannte primäre intraventrikuläre Blutung dar, die ebenso wie die subarachnoidale Blutung gelegentlich parenchymatöse Blutungsanteile besitzen kann [1].

Tab. 1 Ursachen für sekundäre intrazerebrale Blutungen Trauma Neoplasma Arteriovenöse Malformation Kavernom Intrakranielles Aneurysma Venöses Angiom Gerinnungsstörung Durafistel Hämorrhagisch transformierter Hirninfarkt Vaskulitis Sinusvenenthrombose Drogenabusus (v. a. sympathomimetische Drogen)

Intrazerebrale Blutungen sind parenchymatöse Blutungen des Gehirns. Man unterscheidet primäre von sekundären (symptomatischen) ICB.

Literatur

  • 1 Darby D G, Donnan G A, Saling M A. et al . Primary intraventricular hemorrhage: clinical and neuropsychological findings in a prospective stroke series.  Neurology. 1988;  38 68-75
  • 2 Qureshi A I, Tuhrim S, Broderick J P. et al . Spontaneous intracerebral hemorrhage.  N Engl J Med. 2001;  344 1450-1460
  • 3 Kase C S, Mohr J P, Caplan L R. Intracerebral hemorrhage. In: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (eds). Stroke - Pathophysiology, Diagnosis, and Management. Philadelphia: Churchill Livingstone 4th ed. 2004: 327-376
  • 4 Rothwell P M, Coull A J, Silver L E. et al. for the Oxford Vascular Study . Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study).  Lancet. 2005;  366 1773-1783
  • 5 Zhang L F, Yang J, Hong Z. et al . Proportion of different subtypes of stroke in China.  Stroke. 2003;  34 2091-2096
  • 6 Thrift A G, McNeil J J, Forbes A, Donnan G A. Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage.  Hypertension. 1998;  31 1223-1229
  • 7 Segal A Z, Chiu R I, Eggleston-Sexton P M. et al . Low cholesterol as a risk factor for primary intracerebral hemorrhage: a case-control study.  Neuroepidemiology. 1999;  18 185-193
  • 8 Ebrahim S, Sung J, Song Y-M. et al .Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study. Brit Med J 2006 33: 22 originally published online 6 Jun 2006; doi:10.1136/bmj.38855.610324.80
  • 9 Cholesterol Treatment Trialists' (CTT) Collaborators . Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins.  Lancet. 2005;  366 1267-1278
  • 10 Greenberg S M. Cerebral amyloid angiopathy. In: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (eds). Stroke - Pathophysiology, Diagnosis, and Management. Philadelphia: Churchill Livingstone 4th ed 2004: 693-705
  • 11 Koennecke H-C. Cerebral microbleeds on MRI - Prevalence, associations, and potential clinical implications.  Neurology. 2006;  66 165-171
  • 12 Fazekas F, Kleinert R, Roob G. et al . Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds.  AJNR Am J Neuroradiol. 1999;  20 637-642
  • 13 Brott T, Broderick J, Kothari R. et al . Early hemorrhage growth in patients with intracerebral hemorrhage.  Stroke. 1997;  28 1-5
  • 14 Davis S M, Broderick J, Hennerici M. et al . Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage.  Neurology. 2006;  66 1175-1181
  • 15 Mayer S A, Rincon F. Treatment of intracerebral haemorrhage.  Lancet Neurol. 2005;  4 662-672
  • 16 Zazulia A R, Diringer M N, Videen T. Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage.  J Cereb Blood Flow Metab. 2001;  21 804-810
  • 17 Andrews B T, Chiles B W, Olsen W L, Pitts L H. The effect of intracerebral hematoma location on the risk of brain-stem compression and on clinical outcome.  J Neurosurg. 1988;  69 518-522
  • 18 Gebel Jr J M, Jauch E C, Brott T G. et al . Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage.  Stroke. 2002;  33 2636-2641
  • 19 Qureshi A I, Safdar K, Weil J. et al . Predictors of early deterioration and mortality in black Americans with spontaneous intracerebral hemorrhage.  Stroke. 1995;  26 1764-1767
  • 20 Berwaerts J, Dijkhuizen R S, Robb O J. et al . Prediction of functional outcome and in-hospital mortality after admission with oral anticoagulant related intracerebral hemorrhage.  Stroke. 2000;  31 2558-2562
  • 21 Broderick J P, Brott T G, Duldner J E. et al . Volume of intracerebral hemorrhage: a powerful and easy-to-use predictor of 30-day mortality.  Stroke. 1993;  24 987-993
  • 22 Hemphill J C 3rd, Bonovich D C, Besmertis L. et al . The ICH score: a simple, reliable grading scale for intracerebral hemorrhage.  Stroke. 2001;  32 891-897
  • 23 Lisk D R, Pasteur W, Rhoades H. et al . Early presentation of hemispheric intracerebral hemorrhage: prediction of outcome and guidelines for treatment allocation.  Neurology. 1994;  44 133-139
  • 24 Tuhrim S, Horowitz D R, Sacher M, Godbold J H. Validation and comparison of models predicting survival following intracerebral hemorrhage.  Crit Care Med. 1995;  23 950-954
  • 25 Weimar C, Benemann J, Diener H-C. Development and validation of the Essen Intracerebral Haemorrhage Score.  J Neurol Neurosurg Psychiatry. 2006;  77 601-605
  • 26 Bamford J, Sandercock P, Dennis M. et al . A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project - 1981 - 86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage.  J Neurol Neurosurg Psychiatry. 1990;  53 16-22
  • 27 Juvela S. Risk factors for impaired outcome after spontaneous intracerebral hemorrhage.  Arch Neurol. 1995;  52 1193-1200
  • 28 Fogelholm R, Murros K, Rissanen A, Avikainen S. Long term survival after primary intracerebral hemorrhage: a retrospective population based study.  J Neurol Neurosurg Psychiatry. 2005;  76 1534-1538
  • 29 Diringer M N, Edwards D F. Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage.  Crit Care Med. 2001;  29 635-640
  • 30 Mirski M A, Chang C W, Cowan R. Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care.  J Neurosurg Anesthesiol. 2001;  13 83-92
  • 31 Passero S, Burgalassi L, D'Andrea P, Battistini N. Recurrence of bleeding in patients with primary intracerebral hemorrhage.  Stroke. 1995;  26 1189-1192
  • 32 Schwab S, Hamann G, Busch E. et al .Intrazerebrale Blutung. In: Diener HC, Kommission Leitlinien der DGN (Hrsg.). Leitlinien für Diagnostik und Therapie in der Neurologie. Thieme 2005: 247-251
  • 33 Arakawa S, Saku Y, Ibayashi S. et al . Blood pressure control and recurrence of hypertensive brain hemorrhage.  Stroke. 1998;  29 1806-1809
  • 34 O'Donnell H C, Rosand J, Knudsen K A. et al . Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage.  N Engl J Med. 2000;  342 240-245
  • 35 Osborn A G, Blaser S I, Salzman K l. et al .Diagnostic imaging: Brain. Salt Lake City: Amirsys 2004 I. 4 8-9
  • 36 Zhu X L, Chan M S, Poon W S. Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature.  Stroke. 1997;  28 1406-1409
  • 37 Broderick J P, Adams Jr H P, Barsan W. et al . Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association.  Stroke. 1999;  30 905-915
  • 38 Schellinger P D, Jansen O, Fiebach J B. et al . Standardized MRI stroke protocol: Comparison with CT in hyperacute intracerebral hemorrhage.  Stroke. 1999;  30 765-768
  • 39 Kidwell C S, Chalela J A, Saver J L. et al . Comparison of MRI and CT for detection of acute intracerebral hemorrhage.  JAMA. 2004;  292 1823-1830
  • 40 Atlas S W, Mark A S, Grossman R I, Gomori J M. Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T: comparison with spin-echo imaging and clinical application.  Radiology. 1988;  168 803-807
  • 41 Jauch E C, Lindsell C J, Adeoye O. et al .Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke, Jun 2006 doi:10.1161/01.STR.0000229878.93759.a2
  • 42 Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage.  Neurology. 2000;  54 354-361
  • 43 Leira R, Davalos A, Silva Y. et al . Early neurologic deterioration in intracerebral hemorrhage. Predictors and associated factors.  Neurology. 2004;  63 461-467
  • 44 Passero S, Ciacci G, Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage.  Neurology. 2003;  61 1351-1356
  • 45 Poungvarin N, Bhoopat W, Viriyavejakul A. et al . Effects of dexamethasone in primary supratentorial intracerebral hemorrhage.  N Engl J Med. 1987;  316 1229-1233
  • 46 Hart R G, Boop B S, Anderson D C. Oral anticoagulants and intracranial hemorrhage. Facts and hypothesis.  Stroke. 1995;  26 1471-1477
  • 47 Huttner H B, Schellinger P D, Hartmann M. et al . Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates.  Stroke. 2006;  37 1465-1470
  • 48 Sorensen B, Johansen P, Nielsen G L. et al . Reversal of the international normalized ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects.  Blood Coagul Fibrinolysis. 2003;  14 469-477
  • 49 Huttner H B, Jüttler E, Hug A. et al . Antikoagulanzien-assoziierte Hirnblutungen.  Nervenarzt. 2006;  77 671-681
  • 50 Ananthasubramaniam K, Beattie J N, Rosman H S. et al . How safely and for how long can warfarin therapy be withheld in prosthetic heart valve patients hospitalized with a major hemorrhage?.  Chest. 2001;  119 478-484
  • 51 Butler A C, Tait R C. Restarting antikoagulation in prosthetic heart valve patients after intracranial haemorrhage: a 2-year follow up.  Br J Haematol. 1998;  103 1064-1066
  • 52 Leker R R, Abramsky O. Early anticoagulation in patients with prosthetic heart valves and intracerebral hematoma.  Neurology. 1998;  50 1489-1491
  • 53 Gage B F, Watermann A D, Shannon W. et al . Validation of clinical classification schemes for predicting stroke - Results from the national registry of atrial fibrillation.  JAMA. 2001;  28 2864-2870
  • 54 Hill M D, Silver F L, Austin P C, Tu J V. Rate of stroke recurrence in patients with primary intracerebral hemorrhage.  Stroke. 2000;  31 123-127
  • 55 Eckman M H, Rosand J, Knudsen K A. et al . Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis.  Stroke. 2003;  34 1710-1716
  • 56 Viswanathan A, Rakich S M, Engel C. et al . Antiplatelet use after intracerebral hemorrhage.  Neurology. 2006;  66 206-209
  • 57 Passero S, Rocchi R, Rossi S. et al . Seizures after spontaneous supratentorial intracerebral hemorrhage.  Epilepsia. 2002;  43 1175-1180
  • 58 Temkin N R. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.  Epilepsia. 2001;  42 515-524
  • 59 Mendelow A D, Gregson B A, Fernandes H M. et al . Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial.  Lancet. 2005;  365 387-397
  • 60 Adams R E, Diringer M N. Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus.  Neurology. 1998;  50 519-523
  • 61 Mayer S A, Brun N C, Begtrup K. et al . for the recombinant activated factor VII intracerebral hemorrhage trial investigators. Recombinant activated factor VII for acute intracerebral hemorrhage.  N Engl J Med. 2005;  352 777-785

PD Dr. Hans-Christian Koennecke

Abteilung für Neurologie Ev. Krankenhaus Königin Elisabeth Herzberge

Herzbergstr. 79

10362 Berlin

Email: h.koennecke@keh-berlin.de

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