Semin Musculoskelet Radiol 2006; 10(2): 111-124
DOI: 10.1055/s-2006-939029
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Bone Augmentation: Past, Present, and Future

Roberto Blanco Sequeiros1 , Christoph A. Binkert2 , John A. Carrino2
  • 1Oulu University Hospital, Department of Radiology, Oulu, Finland
  • 2Harvard Medical School, Brigham and Women's Hospital, Department of Radiology, Boston, Massachusetts
Further Information

Publication History

Publication Date:
01 April 2006 (online)

ABSTRACT

Painful skeletal and vertebral conditions caused by degeneration, fractures, infection, and neoplasm are common and associated with high morbidity and mortality. Since the introduction of modern orthopedic surgery these conditions have been treated with a multitude of techniques. Bone augmentation and grafting have emerged as integral parts of orthopedic reconstructive, reparative, and palliative surgery. As imaging-guided therapy has developed, image-guided procedures to achieve bone augmentation have also emerged. It is important for the radiologist to understand the materials and methods used to achieve bone augmentation. A variety of materials are available for the application of hone augmentation. Methods used to accomplish bone augmentation often are performed under image guidance. Applications in the axial skeleton include vertebroplasty, kyphoplasty (balloon-assisted vertebroplasty), sacroplasty, and acetabuloplasty. This article discusses the development, current trends, and possible future directions of bone augmentation.

REFERENCES

  • 1 Chapman M. Bone grafting. In: Chapman M Operative Orthopaedics. Philadelphia, PA; J.B. Lippincott Company 1993: 139-149
  • 2 Oikarinen K S, Sandor G K, Kainulainen V T, Salonen-Kemppi M. Augmentation of the narrow traumatized anterior alveolar ridge to facilitate dental implant placement.  Dent Traumatol. 2003;  19 19-29
  • 3 Whang P G, Wang J C. Bone graft substitutes for spinal fusion.  Spine J. 2003;  3 155-165
  • 4 Marx R E. Mandibular reconstruction.  J Oral Maxillofac Surg. 1993;  51 466-479
  • 5 Lexer E. Die Verwenbdung der Freien Knockenplastik Nebst Versuchen Uper Gelenkversteifung und Gelenktransplantation.  Arch Klin Chir. 1908;  86 939-954
  • 6 Craven P L. Osteogenesis by radio-isotope labelled cell populations in implants of bone matrix under the influence of ionizing radiation.  Clin Orthop Relat Res. 1971;  76 231-233
  • 7 Burwell R. Recent Advances in Orthopaedics. London; Churchill 1969
  • 8 Hamer A J, Strachan J R, Black M M, Ibbotson C J, Stockley I, Elson R A. Biochemical properties of cortical allograft bone using a new method of bone strength measurement. A comparison of fresh, fresh-frozen and irradiated bone.  J Bone Joint Surg Br. 1996;  78 363-368
  • 9 Munting E, Wilmart J F, Wijne A, Hennebert P, Delloye C. Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.  Acta Orthop Scand. 1988;  59 34-38
  • 10 Thoren K, Aspenberg P. Ethylene oxide sterilization impairs allograft incorporation in a conduction chamber.  Clin Orthop Relat Res. 1995;  318 259-264
  • 11 Simonds R J, Holmberg S D, Hurwitz R L et al.. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor.  N Engl J Med. 1992;  326 726-732
  • 12 Mellonig J T, Prewett A B, Moyer M P. HIV inactivation in a bone allograft.  J Periodontol. 1992;  63 979-983
  • 13 Burchardt H. The biology of bone graft repair.  Clin Orthop Relat Res. 1983;  174 28-42
  • 14 Pieron A P, Bigelow D, Hamonic M. Bone grafting with Boplant. Results in thirty-three cases.  J Bone Joint Surg Br. 1968;  50 364-368
  • 15 Iwamoto Y, Sugioka Y, Chuman H et al.. Nationwide survey of bone grafting performed from 1980 through 1989 in Japan.  Clin Orthop Relat Res. 1997;  335 292-297
  • 16 Roux F X, Loty B, Brasnu D, Guillemin G. Reconstruction of the anterior face of the base of the skull using coral grafts [in French].  Neurochirurgie. 1988;  34 110-112
  • 17 Guillemin G, Patat J L, Fournie J, Chetail M. The use of coral as a bone graft substitute.  J Biomed Mater Res. 1987;  21 557-567
  • 18 Tomita S, Molloy S, Jasper L E, Abe M, Belkoff S M. Biomechanical comparison of kyphoplasty with different bone cements.  Spine. 2004;  29 1203-1207
  • 19 Hollinger J O, Schmitz J P, Mizgala J W, Hassler C. An evaluation of two configurations of tricalcium phosphate for treating craniotomies.  J Biomed Mater Res. 1989;  23 17-29
  • 20 Comuzzi L, Ooms E, Jansen J A. Injectable calcium phosphate cement as a filler for bone defects around oral implants: an experimental study in goats.  Clin Oral Implants Res. 2002;  13 304-311
  • 21 Stoelinga P J, Blijdorp P A, Ross R R, De Koomen H A, Huybers T J. Augmentation of the atrophic mandible with interposed bone grafts and particulate hydroxylapatite.  J Oral Maxillofac Surg. 1986;  44 353-360
  • 22 Zimmermann R, Gabl M, Lutz M, Angermann P, Gschwentner M, Pechlaner S. Injectable calcium phosphate bone cement Norian SRS for the treatment of intra-articular compression fractures of the distal radius in osteoporotic women.  Arch Orthop Trauma Surg. 2003;  123 22-27
  • 23 Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics.  Clin Orthop Relat Res. 1981;  157 259-278
  • 24 Ooms E M, Wolke J G, van der Waerden J P, Jansen J A. Trabecular bone response to injectable calcium phosphate (Ca-P) cement.  J Biomed Mater Res. 2002;  61 9-18
  • 25 Belkoff S M, Mathis J M, Erbe E M, Fenton D C. Biomechanical evaluation of a new bone cement for use in vertebroplasty.  Spine. 2000;  25 1061-1064
  • 26 Barrows T H. Degradable implant materials: a review of synthetic absorbable polymers and their application.  Clin Mater. 1986;  1 233-257
  • 27 Suuronen R, Kallela I, Lindqvist C. Bioabsorbable plates and screws: current state of the art in facial fracture repair.  J Craniomaxillofac Trauma. 2000;  6 19-27 , (discussion 28-30)
  • 28 Aderriotis D, Sandor G K. Outcomes of irradiated polyglactin 910 Vicryl Rapide fast-absorbing suture in oral and scalp wounds.  J Can Dent Assoc. 1999;  65 345-347
  • 29 Paltrinieri M, Trentani C. Modification of hip arthroprosthesis [in Italian].  Chir Organi Mov. 1971;  60 85-95
  • 30 Faber C, Stallmann H P, Lyaruu D M et al.. Release of antimicrobial peptide Dhvar-5 from polymethylmethacrylate beads.  J Antimicrob Chemother. 2003;  51 1359-1364
  • 31 Healey J H, Shannon F, Boland P, DiResta G R. PMMA to stabilize bone and deliver antineoplastic and antiresorptive agents.  Clin Orthop Relat Res. 2003;  415(Suppl) S263-S275
  • 32 Li R H, Bouxsein M L, Blake C A et al.. rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model.  J Orthop Res. 2003;  21 997-1004
  • 33 Ruhe P Q, Hedberg E L, Padron N T, Spauwen P H, Jansen J A, Mikos A G. rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites.  J Bone Joint Surg Am. 2003;  85 75-81
  • 34 Seeherman H, Li R, Wozney J. A review of preclinical program development for evaluating injectable carriers for osteogenic factors.  J Bone Joint Surg Am. 2003;  85 96-108
  • 35 Rosa M A, Maccauro G, Sgambato A et al.. Acrylic cement added with antiblastics in the treatment of bone metastases. Ultrastructural and in vitro analysis.  J Bone Joint Surg Br. 2003;  85 712-716
  • 36 Ladron de Guevara-Fernandez S, Ragel C V, Vallet-Regi M. Bioactive glass-polymer materials for controlled release of ibuprofen.  Biomaterials. 2003;  24 4037-4043
  • 37 Clokie C, Sàndor G. Bone: present and future. In: Babush C Dental Implants: The Art and Science. Philadelphia, PA; W.B. Saunders Company 2001: 59-84
  • 38 Celeste A J, Iannazzi J A, Taylor R C et al.. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.  Proc Natl Acad Sci USA. 1990;  87 9843-9847
  • 39 Wozney J M, Rosen V, Byrne M, Celeste A J, Moutsatsos I, Wang E A. Growth factors influencing bone development.  J Cell Sci Suppl. 1990;  13 149-156
  • 40 Ross R, Raines E W, Bowen-Pope D F. The biology of platelet-derived growth factor.  Cell. 1986;  46 155-169
  • 41 Qian J J, Bhatnagar R S. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen.  J Biomed Mater Res. 1996;  31 545-554
  • 42 Owen M. Marrow stromal stem cells.  J Cell Sci Suppl. 1988;  10 63-76
  • 43 Galibert P, Deramond H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty [in French].  Neurochirurgie. 1987;  33 166-168
  • 44 Hardouin P, Fayada P, Leclet H, Chopin D. Kyphoplasty.  Joint Bone Spine. 2002;  69 256-261
  • 45 Garant M. Sacroplasty: a new treatment for sacral insufficiency fracture.  J Vasc Interv Radiol. 2002;  13 1265-1267
  • 46 Pommersheim W, Huang-Hellinger F, Baker M, Morris P. Sacroplasty: a treatment for sacral insufficiency fractures.  AJNR Am J Neuroradiol. 2003;  24 1003-1007
  • 47 Hierholzer J, Anselmetti G, Fuchs H, Depriester C, Koch K, Pappert D. Percutaneous osteoplasty as a treatment for painful malignant bone lesions of the pelvis and femur.  J Vasc Interv Radiol. 2003;  14 773-777
  • 48 Weill A, Kobaiter H, Chiras J. Acetabulum malignancies: technique and impact on pain of percutaneous injection of acrylic surgical cement.  Eur Radiol. 1998;  8 123-129
  • 49 Cotten A, Demondion X, Boutry N et al.. Therapeutic percutaneous injections in the treatment of malignant acetabular osteolyses.  Radiographics. 1999;  19 647-653
  • 50 Cotten A, Deprez X, Migaud H, Chabanne B, Duquesnoy B, Chastanet P. Malignant acetabular osteolyses: percutaneous injection of acrylic bone cement.  Radiology. 1995;  197 307-310
  • 51 Gailloud P, Beauchamp N J, Martin J B, Murphy K J. Percutaneous pediculoplasty: polymethylmethacrylate injection into lytic vertebral pedicle lesions.  J Vasc Interv Radiol. 2002;  13 517-521
  • 52 Carrino J A, Chan R, Vaccaro A R. Vertebral augmentation: vertebroplasty and kyphoplasty.  Semin Roentgenol. 2004;  39 68-84
  • 53 Tomita S, Molloy S, Abe M, Belkoff S M. Ex vivo measurement of intravertebral pressure during vertebroplasty.  Spine. 2004;  29 723-725
  • 54 Graham J, Ries M, Pruitt L. Effect of bone porosity on the mechanical integrity of the bone-cement interface.  J Bone Joint Surg Am. 2003;  85 1901-1908
  • 55 Nussbaum D A, Gailloud P, Murphy K. The chemistry of acrylic bone cements and implications for clinical use in image-guided therapy.  J Vasc Interv Radiol. 2004;  15 121-126
  • 56 De S, Vazquez B. The effect of cross-linking agents on acrylic bone cements containing radiopacifiers.  Biomaterials. 2001;  22 2177-2181
  • 57 Kallmes D F, Jensen M E. Percutaneous vertebroplasty.  Radiology. 2003;  229 27-36
  • 58 Belkoff S M, Maroney M, Fenton D C, Mathis J M. An in vitro biomechanical evaluation of bone cements used in percutaneous vertebroplasty.  Bone. 1999;  25 23S-26S
  • 59 Bhambri S K, Gilbertson L N. Micromechanisms of fatigue crack initiation and propagation in bone cements.  J Biomed Mater Res. 1995;  29 233-237
  • 60 Tomita S, Kin A, Yazu M, Abe M. Biomechanical evaluation of kyphoplasty and vertebroplasty with calcium phosphate cement in a simulated osteoporotic compression fracture.  J Orthop Sci. 2003;  8 192-197
  • 61 Neut D, van de Belt H, van Horn J R, van der Mei H C, Busscher H J. The effect of mixing on gentamicin release from polymethylmethacrylate bone cements.  Acta Orthop Scand. 2003;  74 670-676
  • 62 Youngman J R, Ridgway G L, Haddad F S. Antibiotic-loaded cement in revision joint replacement.  Hosp Med. 2003;  64 613-616
  • 63 Tahara Y, Ishii Y. Apatite cement containing cis-diamminedichloroplatinum implanted in rabbit femur for sustained release of the anticancer drug and bone formation.  J Orthop Sci. 2001;  6 556-565
  • 64 Belkoff S M, Molloy S. Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty.  Spine. 2003;  28 1555-1559
  • 65 Kobayashi K, Shimoyama K, Nakamura K, Murata K. Percutaneous vertebroplasty immediately relieves pain of osteoporotic vertebral compression fractures and prevents prolonged immobilization of patients.  Eur Radiol. 2005;  15 360-367
  • 66 Gaughen Jr J R, Jensen M E, Schweickert P A, Marx W F, Kallmes D F. The therapeutic benefit of repeat percutaneous vertebroplasty at previously treated vertebral levels.  AJNR Am J Neuroradiol. 2002;  23 1657-1661
  • 67 Gangi A, Guth S, Imbert J P, Marin H, Dietemann J L. Percutaneous vertebroplasty: indications, technique, and results.  Radiographics. 2003;  23 e10
  • 68 Woertler K. Benign bone tumors and tumor-like lesions: value of cross-sectional imaging.  Eur Radiol. 2003;  13 1820-1835
  • 69 Mahnken A H, Wildberger J E, Gehbauer G et al.. Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography.  AJR Am J Roentgenol. 2002;  178 1429-1436
  • 70 Ghanem N, Altehoefer C, Hogerle S et al.. Comparative diagnostic value and therapeutic relevance of magnetic resonance imaging and bone marrow scintigraphy in patients with metastatic solid tumors of the axial skeleton.  Eur J Radiol. 2002;  43 256-261
  • 71 Altehoefer C, Ghanem N, Hogerle S, Moser E, Langer M. Comparative detectability of bone metastases and impact on therapy of magnetic resonance imaging and bone scintigraphy in patients with breast cancer.  Eur J Radiol. 2001;  40 16-23
  • 72 Zampa V, Bargellini I, Michelassi M C et al.. MR evaluation of bone cysts treated with intracavital steroid injection.  Eur Radiol. 2003;  13 1348-1356
  • 73 Moulopoulos L A, Dimopoulos M A, Alexanian R, Leeds N E, Libshitz H I. Multiple myeloma: MR patterns of response to treatment.  Radiology. 1994;  193 441-446
  • 74 Parkkola R K, Mattila K T, Heikkila J T et al.. Dynamic contrast-enhanced MR imaging and MR-guided bone biopsy on a 0.23 T open imager.  Skeletal Radiol. 2001;  30 620-624
  • 75 Adam G, Bucker A, Nolte-Ernsting C, Tacke J, Gunther R W. Interventional MR imaging: percutaneous abdominal and skeletal biopsies and drainages of the abdomen.  Eur Radiol. 1999;  9 1471-1478
  • 76 Blanco Sequeiros R, Klemola R, Ojala R et al.. MRI-guided trephine biopsy and fine-needle aspiration in the diagnosis of bone lesions in low-field (0.23 T) MRI system using optical instrument tracking.  Eur Radiol. 2002;  12 830-835
  • 77 Jolesz F A. Interventional and intraoperative MRI: a general overview of the field.  J Magn Reson Imaging. 1998;  8 3-7
  • 78 Kettenbach J, Kacher D F, Koskinen S K et al.. Interventional and intraoperative magnetic resonance imaging.  Annu Rev Biomed Eng. 2000;  2 661-690
  • 79 Sequeiros R B, Hyvonen P</, Sequeiros A B et al.. MR imaging-guided laser ablation of osteoid osteomas with use of optical instrument guidance at 0.23 T.  Eur Radiol. 2003;  13 2309-2314
  • 80 Mack M G, Straub R, Eichler K et al.. Percutaneous MR imaging-guided laser-induced thermotherapy of hepatic metastases.  Abdom Imaging. 2001;  26 369-374
  • 81 Mala T, Edwin B, Samset E et al.. Magnetic-resonance-guided percutaneous cryoablation of hepatic tumours.  Eur J Surg. 2001;  167 610-617
  • 82 Perlet C, Schneider P, Amaya B et al.. MR-Guided vacuum biopsy of 206 contrast-enhancing breast lesions.  Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 2002;  174 88-95
  • 83 Hynynen K, Pomeroy O, Smith D N et al.. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study.  Radiology. 2001;  219 176-185
  • 84 Zubritsky E. MRI for gene expression.  Anal Chem. 2000;  72 319A-320A
  • 85 Ichikawa T, Hogemann D, Saeki Y et al.. MRI of transgene expression: correlation to therapeutic gene expression.  Neoplasia. 2002;  4 523-530
  • 86 Madio D P, van Gelderen P, DesPres D et al.. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression.  J Magn Reson Imaging. 1998;  8 101-104
  • 87 Schaefer O, Lohrmann C, Markmiller M, Uhrmeister P, Langer M. Technical innovation. Combined treatment of a spinal metastasis with radiofrequency heat ablation and vertebroplasty.  AJR Am J Roentgenol. 2003;  180 1075-1077
  • 88 Dehdashti A R, Martin J B, Jean B, Rufenacht D A. PMMA cementoplasty in symptomatic metastatic lesions of the S1 vertebral body.  Cardiovasc Intervent Radiol. 2000;  23 235-237
  • 89 Masala S, Roselli M, Massari F et al.. Radiofrequency heat ablation and vertebroplasty in the treatment of neoplastic vertebral body fractures.  Anticancer Res. 2004;  24 3129-3133

John A CarrinoM.D. M.P.H. 

Harvard Medical School, Brigham and Women's Hospital

Department of Radiology, 75 Francis Street, Boston, MA 02115

    >