A Novel Approach to C-Trimethylsilyl-1,3-azoles

Evgenij V. Zarudnitskii; Igor I. Pervak; Anatolij S. Merkulov; Aleksandr A. Yurchenko; Andrej A. Tolmachev; Aleksandr M. Pinchuk

doi:10.1055/s-2006-926412

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Synthesis 2006(8): 1279-1282
DOI: 10.1055/s-2006-926412

PAPER

A Novel Approach to C-Trimethylsilyl-1,3-azoles

Evgenij V. Zarudnitskii*^a, Igor I. Pervak^a, Anatolij S. Merkulov^a, Aleksandr A. Yurchenko^a, Andrej A. Tolmachev^b, Aleksandr M. Pinchuk^a
^a Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska str. 5, 02094 Kiev, Ukraine
e-Mail: zhz@bpci.kiev.ua;
^b National Taras Shevchenko University, Volodymyrska str. 62, 01033 Kiev, Ukraine

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Publication History

Received 19 September 2005
Publication Date:
28 March 2006 (online)

Abstract
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Abstract

Direct silylation of 1,3-azoles with bromotrimethylsilane in the presence of triethylamine was investigated. 5-Phenyloxazole, benzoxazole, 1-methyl-1,2,4-triazole, 2-aryl-1,3,4-oxa- and thiadiazoles were found to give the corresponding 2- or 5-trimethylsilyl derivatives.

Key words

azoles - silylation - heterocycles - electrophilic substitution - silicon

References

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