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Synthesis 2006(4): 629-632  
DOI: 10.1055/s-2006-926310
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 4-Substituted 7-Azaindole Derivatives via Pd-Catalyzed C-N and C-O Coupling

Michael Thutewohl*, Hartmut Schirok, Samir Bennabi, Santiago Figueroa-Pérez
Bayer HealthCare AG, Pharma Research, 42096 Wuppertal, Germany
Fax: +41(81)7552736; e-Mail: mthutewohl@europe.sial.com;
Further Information

Publication History

Received 15 June 2005
Publication Date:
19 January 2006 (online)

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Abstract

The efficient substitution of 4-chloro-7-azaindoles by anilines and phenols via palladium-catalyzed C-N and C-O coupling is reported.

Key words

7-azaindoles - palladium catalysis - C-N coupling - C-O coupling - heterocycles

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1

Current address: Sigma-Aldrich Production GmbH, Industriestraße 25, 9471 Buchs, SG, Switzerland.

2

Current address: Bayer CropScience SA, Fungicide Research, BP 9163, 69263 Lyon, France.