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Int J Sports Med 2006; 27(12): 951-958
DOI: 10.1055/s-2006-923901
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

NOS3 Gene Polymorphisms and Exercise Hemodynamics in Postmenopausal Women

B. D. Hand1 , S. D. McCole2 , M. D. Brown1 , J. J. Park1 , R. E. Ferrell3 , A. Huberty4 , L. W. Douglass4 , J. M. Hagberg1
  • 1Department of Kinesiology, University of Maryland, College Park, MD, USA
  • 2Department of Exercise Science and Physical Education, McDaniel College, Westminster, MD, USA
  • 3Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
  • 4Biometrics Program, Department of Avian and Animal Sciences, University of Maryland, College Park, MD, USA
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Publication History

Accepted after revision: November 30, 2005

Publication Date:
08 June 2006 (online)

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Abstract

We tested whether the G894T and T-786C NOS3 polymorphisms were associated with exercise cardiovascular (CV) hemodynamics in sedentary, physically active, and endurance-trained postmenopausal women. CV hemodynamic parameters including heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressures and cardiac output (Q), as determined by acetylene rebreathing, stroke volume (SV), arteriovenous oxygen difference (a-vO2 diff), and total peripheral resistance (TPR) were measured during submaximal (40, 60, 80 %) and maximal (∼ 100 % V·O2max) exercise. NOS3 G894T genotype was not significantly associated, either independently or interactively with habitual physical activity (PA) level, with SBP, Q, TPR, or a-vO2 diff during submaximal or maximal exercise. However, NOS3 894T non-carriers had a higher submaximal exercise HR than NOS3 894T allele carriers (120 ± 2 vs. 112 ± 2 beats/min, p = 0.007). NOS3 894T allele carriers had a higher SV than 894T non-carriers (78 ± 2 vs. 72 ± 2 ml/beat, p = 0.03) during submaximal exercise. NOS3 894T non-carriers also had a higher maximal exercise HR averaged across habitual PA groups than T allele carrier women (165 ± 2 vs. 158 ± 2 beats/min, p = 0.04). NOS3 894T allele carriers also tended to have a higher SV during maximal exercise than 894T non-carriers (70 ± 2 vs. 64 ± 2 ml/beat, p = 0.08). NOS3 T-786C genotype was not significantly associated, either independently or interactively, with any of the CV hemodynamic measures during submaximal or maximal exercise. These results suggest an association of NOS3 G894T genotype with submaximal and maximal exercise CV hemodynamic responses, especially HR, in postmenopausal women.

Key words

Heart rate - cardiac output - stroke volume - genetics

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PhD James M. Hagberg

Department of Kinesiology, HHP Bldg Rm. 2134E
University of Maryland

College Park, MD 20742-2611 USA

Phone: + 3014052487

Fax: + 30 14 05 55 78

Email: hagberg@umd.edu

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