Quetiapine in the Treatment of Rapid-Cycling Bipolar II Disorder With Comorbid Anxiety and Social Phobia

In patients with bipolar illness, rapid cycling - defined as four or more episodes per year - is recognized as a condition that is relatively resistant to treatment [3]. We report a case of a woman with rapid-cycling bipolar II disorder who was successfully treated with quetiapine, a psychotropic agent that has previously been used for the treatment of schizophrenia and mania [2] [4] [6]. Within 6 months of initiating treatment, her mood swings subsided and her comorbid conditions of anxiety and social phobia improved.

References

• 1 Calabrese J R, Keck PE J r, Macfadden W, Minkwitz M, Ketter T A, Weisler R H, Cutler A J, McCoy R, Wilson E, Mullen J, and The BOLDER Study G roup. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression.  Am J Psychiatry. 2005;  162(7) 1351-60
• 2 Grohmann R, Engel R R, Geissler K H, Ruther E. Psychotropic drug use in psychiatric inpatients: recent trends and changes over time-data from the AMSP study.  Pharmacopsychiatry. 2004;  37 Suppl 1 S27-S38
• 3 Kupka R, Luckenbaugh D, Post R, Leverich G, Nolen W. Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies.  J Clin Psychiatry. 2003;  64 1483-1494
• 4 Vieta E, Mullen J, Brecher M, Paulsson B, Jones M. Quetiapine monotherapy for mania associated with bipolar disorder: combined analysis of two international, double-blind, randomised, placebo-controlled studies. Curr Med Res Opin 2005: in press
• 5 Vieta E, Parramon G, Padress E. et al . Quetiapine in the treatment of rapid cycling bipolar disorder.  Bipolar Disord. 2002;  4 335-340
• 6 Yatham L N, Paulsson B, Mullen J, Vågerö M. Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania.  J Clin Psychopharmacol. 2004;  24 599-606
• 7 Yildiz A, Sachs G. Characteristics of rapid cycling bipolar-I patients in a bipolar specialty clinic.  J Affect Disord. 2004;  79 247-251