Mechanismen und Therapiestrategien zur Angiogeneseinduktion in der Plastischen Chirurgie

Zusammenfassung

Die Plastische Chirurgie hat schon immer ein besonderes Interesse an angiogenetischen Regulierungsprozessen im Rahmen der Gewebeheilung gehabt. Viele der chirurgischen Pionierleistungen früherer Tage, wie zum Beispiel die verschiedenen plastisch-chirurgischen Techniken des gestielten Gewebetransfers und der freien mikrovaskulären Gewebetransplantation, sind heute chirurgischer Standard, aber erst seit 10 bis 15 Jahren haben wir auch die technischen und apparativen Möglichkeiten, uns zunehmend auch mit den molekularen Mechanismen der funktionellen Blutgefäßbildung in vivo zu beschäftigen und diese besser zu verstehen. Dieser Übersichtsartikel will eine zusammenfassende Darstellung verschiedener Mechanismen und Therapiestrategien zur Angiogeneseinduktion liefern, welche in der Plastischen Chirurgie klinisch und experimentell in diesem Zusammenhang beobachtet und angewendet werden können.

Abstract

Plastic Surgery has been focussing on wound healing and therefore also on angiogenic regulatory mechanisms since many years. Nowadays most of the pioneering work including different plastic surgical techniques like tissue transfer and microsurgery are surgical standard. But only since 10 to 15 years we have tools and methods to investigate the molecular mechanisms of functional angiogenesis in vivo. This article presents some mechanisms and therapeutic strategies for angiogenesis, which can be applied both clinically and experimentally in plastic surgery.

Schlüsselwörter

Plastische Chirurgie - Angiogenese - Mechanismen - Therapien

Key words

Plastic surgery - angiogenesis - mechanisms - therapy

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