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Synthesis 2005(2): 255-259  
DOI: 10.1055/s-2004-834937
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Spiro[pyrrolidine-2,2′-adamantane] Nitrones and Nitroxides

Cecília P. Sára, Erzsébet Őszb, József Jekőc, Kálmán Hideg*a
a Institute of Organic and Medicinal Chemistry, University of Pécs, P.O. Box 99, 7602 Pécs, Hungary
Fax: +36(72)536219; e-Mail: kalman.hideg@aok.pte.hu;
b Department of Biochemistry and Medical Chemistry, University of Pécs, P.O. Box 99, 7602 Pécs, Hungary
c ICN Hungary, P.O. Box 1, 4440 Tiszavasvári, Hungary
Further Information

Publication History

Received 29 September 2004
Publication Date:
01 December 2004 (online)

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Abstract

Starting from 2-nitroadamantane, spiro[pyrrolidine-2,2′-adamantane] nitrones and nitroxides were synthesised as new lipophilic spin traps and spin labels. The reduction of nitrones and nitroxides­ offers a new route to aminoadamantane derivatives.

Key words

adamantane - free radicals - heterocycles - nitrone - Grignard reaction

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