CeCl₃·7H₂O/NaI-Promoted Stereoselective Aldol Coupling of α,β-Acetylenic Ketones

Abstract

A simple and highly stereoselective method has been developed for the synthesis of (Z)-β-iodo Baylis-Hillman adducts using CeCl₃·7H₂O/NaI as an inexpensive and readily available reagent system. High conversions and enhanced Z-selectivity together with the environmentally benign nature of the CeCl₃/NaI reagent system makes this method an attractive alternative to established methods.

Key words

cerium compounds - three component reaction - β-iodovinyl ketones

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