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Am J Perinatol 2003; 20(8): 465-476
DOI: 10.1055/s-2003-45387
ORIGINAL ARTICLE

Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Lymphocyte Subpopulations in Bronchopulmonary Dysplasia

Praveen Ballabh1 , Maciej Simm2 , Jaishree Kumari2 , Alfred N. Krauss3 , Ajey Jain3 , Peter A.M. Auld3 , Susanna Cunningham-Rundles4
  • 1Division of Newborn Unit, Westchester Medical Center, Valhalla, New York
  • 2The New York Presbyterian Cornell Medical Center
  • 3Department of Pediatrics, Weill Medical College of Cornell University, New York, New York
  • 4Cellular Immunology Laboratory, Weill Medical College of Cornell University, New York, New York
Further Information

Publication History

Publication Date:
02 January 2004 (online)

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ABSTRACT

A key role for inflammation in the etiology of bronchopulmonary dysplasia (BPD) has been proposed. In the present study we have evaluated lymphocyte subpopulations in 39 premature infants with respiratory distress syndrome (RDS) who did or did not develop BPD. The absolute number of lymphocytes was lower among infants with RDS who developed BPD compared with those who did not over the first two weeks of life (p < 0.020) as were percentage and absolute number of CD4+ T cells. By contrast, the proportions of CD3+CD8+ lymphocyte cells were not statistically different between non-BPD and BPD infants. B cell percentage was significantly decreased in BPD infants only on day 7. NK “bright” cells (CD56+) were highly enriched in all RDS groups. Interestingly, the percentage of CD4+ T cells expressing CD62L was selectively reduced in BPD infants. As a whole these data suggest that reduction of CD4+ T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD.

KEYWORDS

Bronchopulmonary dysplasia - lymphocyte subsets - L-selectin

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