A Novel Cu-catalysed Three-component One-pot Synthesis of Dihydro­pyrimidin-2(1H)-ones Using Microwaves under Solvent-free Conditions

Mukut Gohain; Dipak Prajapati; Jagir S. Sandhu

doi:10.1055/s-2003-43374

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Synlett 2004(2): 0235-0238
DOI: 10.1055/s-2003-43374

LETTER

A Novel Cu-catalysed Three-component One-pot Synthesis of Dihydropyrimidin-2(1H)-ones Using Microwaves under Solvent-free Conditions

Mukut Gohain^a, Dipak Prajapati*^a, Jagir S. Sandhu^b
^a Medicinal Chemistry Division, Regional Research Laboratory, Jorhat - 785 006, India
Fax: +91(376)2370011; e-Mail: dr_dprajapati@yahoo.co.uk; e-Mail: drugs@csir.res.in;
^b Department of Chemistry, Panjabi University, Patiala-147 002

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Publication History

Received 4 September 2003
Publication Date:
18 December 2003 (online)

Abstract
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Abstract

Cupric chloride dihydrate catalyzes the three-component Biginelli condensation between an aldehyde, a β-ketoester and urea or thiourea under microwave irradiation in the absence of solvent to yield various substituted 3,4-dihydropyrimidin-2(1H)-ones. The reaction is also effective when performed at room temperature in acetonitrile or at 100 °C in a solvent free approach, without any side reactions as observed by Biginelli and others.

Key words

Biginelli condensation - cupric chloride - cupric sulphate - dihydropyrimidinones, - three-component reactions

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