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Int J Sports Med 2003; 24(8): 551-558
DOI: 10.1055/s-2003-43266
Physiology & Biochemistry
© Georg Thieme Verlag Stuttgart · New York

Heredity and Pituitary Response to Exercise-Related Stress in Trained Men

L.  Di Luigi1 , L.  Guidetti1 , C.  Baldari1 , F.  Romanelli2
  • 1Endocrinology Unit, Laboratory of Endocrine Research, Istituto Universitario di Scienze Motorie (IUSM), Rome, Italy
  • 2Division of Andrology, University of Rome “La Sapienza”, Rome, Italy
Further Information

Publication History

Accepted after revision: February 15, 2003

Publication Date:
04 November 2003 (online)

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Abstract

To evaluate the role of heredity in the pituitary responses to exercise-related stress, serum ACTH, β-endorphin, cortisol, GH, and PRL responses to a thirty-minute treadmill exercise at individual anaerobic threshold were evaluated in nine pairs of male monozygotic twin athletes. Hormone evaluations were performed before (-30, -15, 0 pre) and after exercise (0 post, + 15, + 30, + 45, + 60, and + 90 min). The intraclass correlation coefficient (expression of within-pair resemblance) was computed for each hormone before and after exercise as area under curves (AUC), absolute values, and percentage of variation, respectively. The exercise-related stress condition induced a significant increase for all evaluated hormones before (anticipatory response) and/or after exercise. As new data, we observed: 1) A significant within-pair resemblance for exercise-related GH and PRL increase (AUCs and/or absolute values), and for the percentage of variation of cortisol, and 2) the lack of significant resemblance for the observed increase of ACTH, cortisol and absolute β-endorphin serum concentration. This first co-twin control study supports the hypothesis that, in trained men, there are probably different relative roles for the influence of genetic factors on the pituitary hormones involved in physiological adaptation to exercise-related stress. Furthermore, our findings justify further investigations into this topic.

Key words

Adrenocorticotropin - β-endorphin - cortisol - exercise - growth hormone - prolactin - twins

References

  • 1 Akamine Y, Kato K, Ibayashi H. Studies on changes in the concentration of serum adrenal androgens in pubertal twins.  Acta Endocrinol. 1980;  93 356-364
    PubMedGoogle Scholar
  • 2 Baldari C, Guidetti L. A simple method for individual anaerobic threshold as predictor of max lactate steady state.  Med Sci Sports Exerc. 2000;  32 1798-1802
    CrossrefPubMedGoogle Scholar
  • 3 Bouchard C, Lesage R, Lortie G, Simoneau J A, Hamel P, Boulay M R, Pérusse L, Thériault G, Leblanc C. Aerobic performance in brothers, dizygotic and monozygotic twins.  Med Sci Sports Exerc. 1986;  18 639-646
    PubMedGoogle Scholar
  • 4 Cumming D C. Hormones and athletic performance. In: Felig P, Baxter JD, Frohman LA, (eds). Endocrinology and Metabolism New York; Mc Graw Hill 1995: 1837-1886
    Google Scholar
  • 5 Di Luigi L, Guidetti L, Pigozzi F, Baldari C, Casini A, Nordio M, Romanelli F. Acute amino acids supplementation enhances pituitary responsiveness in athletes.  Med Sci Sports Exerc. 1999;  31 1748-1754
    PubMedGoogle Scholar
  • 6 Di Luigi L, Guidetti L, Baldari C, Romanelli F, Conte D. Acetylsalicilic acid inhibits the pituitary response to exercise-related stress in humans.  Med Sci Sports Exerc. 2001;  33 2029-2035
    PubMedGoogle Scholar
  • 7 Fagard R, Bielen E, Amery A. Heritability of aerobic power and anaerobic energy generation during exercise.  J Appl Physiol. 1991;  7 357-362
    PubMedGoogle Scholar
  • 8 Feitosa M F, Rice T, Rosmond R, Borecki I B, An P, Gagnon I, Leon A S, Skinner J S, Wilmore J H, Bouchard C, Rao D C. A genetic study of cortisol measured before and after endurance training: the HERITAGE Family Study.  Metabolism. 2002;  51 360-365
    CrossrefPubMedGoogle Scholar
  • 9 Guidetti L, Musulin A, Baldari C. Physiological factors in middleweight boxing performance.  J Sports Med Phys Fitness. 2002;  42 309-314
    PubMedGoogle Scholar
  • 10 Loos R, Thomis M, Maes H H, Beunen G, Claessens A L, Derom C, Legius E, Derom R, Vlietinck R. Gender specific regional changes in genetic structure of muscularity in early adolescence.  J Appl Physiol. 1997;  82 1802-1810
    PubMedGoogle Scholar
  • 11 Hamel P, Simoneau J A, Lortie G, Boulay M R, Bouchard C. Heredity and muscle adaptation to endurance training.  Med Sci Sports Exerc. 1986;  18 690-696
    PubMedGoogle Scholar
  • 12 Hrubec Z, Robinette C D. The study of human twins in medical research.  N Engl J Med. 1984;  310 435-441
    PubMedGoogle Scholar
  • 13 Kirschbaum C, Wüst S, Faig H G, Hellhammer D H. Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans.  J Clin Endocrinol Metab. 1992;  75 1526-1530
    CrossrefPubMedGoogle Scholar
  • 14 Klissouras V. Heritability of adaptative variation.  J Appl Physiol. 1971;  31 338-346
    PubMedGoogle Scholar
  • 15 Klissouras V, Casini B, Di Salvo V, Faina M, Marini C, Pigozzi F, Pittaluga M, Spataro A, Taddei F, Parisi P. Genes and Olympic performance: a co-twin study.  Int J Sports Med. 2001;  22 250-255
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Komi P V, Karlson J. Physical performance, skeletal muscle enzyme activities and fibre type in monozygous and dizygous twins of both sexes.  Acta Physiol Scand. 1979;  462 1-28
    PubMedGoogle Scholar
  • 17 Maes H H, Beuven G P, Vlietinck R F, Neale M C, Thomis M, Vanden Eynde B V, Lysens R, Simons J, Derom C, Derom R. Inheritance of physical fitness in 10-year-old twins and their parents.  Med Sci Sports Exerc. 1996;  28 1479-1491
    PubMedGoogle Scholar
  • 18 Meikle A W, Stringham J D, Woodward M G, Bishop D T. Heritability of variation of plasma cortisol levels.  Metabolism. 1988;  37 514-517
    CrossrefPubMedGoogle Scholar
  • 19 Mason J W. A review of psychoendocrine research on the pituirary-adrenal cortical system.  Psychosom Med. 1968;  30 576-607
    PubMedGoogle Scholar
  • 20 Oppert J M, Nadeau A, Tremblay A, Després J P, Thériault G, Bouchard C. Negative energy balance with exercise in identical twins: plasma glucose and insulin responses.  Am J Physiol. 1997;  272 248-254
    PubMedGoogle Scholar
  • 21 Ping A N, Rice T, Gagnon J, Hong Y, Leon A S, Skinner J S, Wilmore J H, Bouchard C, Rao D C. A genetic study of dehydroepiandrosterone sulfate measured before and after a 20-week endurance exercise-training program: the HERITAGE family study.  Metabolism. 2000;  49 298-304
    CrossrefPubMedGoogle Scholar
  • 22 Pohelman E T, Tremblay A, Nadeau A, Dussault J, Thériault G, Bouchard C. Heredity and changes in hormones and metabolic rates with short-term training.   Am J Physiol. 1986;  250 E711-717
    PubMedGoogle Scholar
  • 23 Pritchard J, Després J P, Gagnon J, Tchernof A, Nadeau A, Tremblay A, Bouchard C. Plasma adrenal, gonadal, and coniugated steroids following long-term exercise-induced negative energy balance in identical twins.  Metabolism. 1999;  48 1120-1127
    CrossrefPubMedGoogle Scholar
  • 24 Sotos J F. Overgrowth. Section IV. Genetic disorders associated with overgrowth.  Clin Ped. 1997;  36 39-49
    PubMedGoogle Scholar
  • 25 Tremblay A, Poehlman E T, Despres J P, Theriault G, Danforth E, Bouchard C. Endurance training with constant energy intake in identical twins: changes over time in energy expenditure and related hormones.  Metabolism. 1997;  46 499-503
    CrossrefPubMedGoogle Scholar
  • 26 Tremblay M S, Chu S Y. Hormonal response to exercise: methodological considerations. In: Warren MP, Costantini NW (eds) Sports Endocrinology. Humana Press Inc Totowa, NJ; 2000: 1-30
    Google Scholar
  • 27 Van Beaumont W. Evaluation of hemoconcentration from hematocrit measurements.  J Appl Physiol. 1972;  32 712-713
    PubMedGoogle Scholar
  • 28 Winer B J. Statistical Principles in Experimental Design. McGraw-Hill Book Co. (ed). New York;. 1971: 518-539
    Google Scholar
  • 29 Wisor J P, Takahashi J S. Molecular genetic approaches to the identity and function of circadian clock genes. In: Turek FW, Zee PC (eds). Regulation of Sleep and Circadian Rhythms. Marcel Dekker; New York. 1999 133: 369-396
    Google Scholar
  • 30 Wüst S, Federenko I, Hellhammer D H, Kirschbaum C. Genetic factors, perceived chronic stress, and the free cortisol response to awakening.  Psychoneuroendocrinology. 2000;  25 707-720
    PubMedGoogle Scholar

Prof. L. Di Luigi, MD

Laboratory of Endocrine Research · Istituto Universitario di Scienze Motorie/IUSM

Piazza Lauro de Bosis 15 · 00194 Rome · Italy ·

Phone: +39 06 36733231

Fax: +39 06 36733231

Email: iusm.endocrinol@iusm.it

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