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Synthesis 2003(15): 2292-2294  
DOI: 10.1055/s-2003-42409
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

An Expedient Synthesis of Benzo[h]quinazolin-4(3H)-one: Structure of Samoquasine A Revisited

Manas Chakrabarty*a, Sandipan Sarkara, Yoshihiro Harigayab
a Department of Chemistry, Bose Institute, 93/1, A.P.C. Road, Kolkata 700009, India
Fax: +91(33)23506790; e-Mail: chakmanas@yahoo.co.in;
b School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108, Japan
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Publication History

Received 24 June 2003
Publication Date:
29 September 2003 (online)

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Abstract

An expedient four-step synthesis of benzo[h]quinazolin-4(3H)-one (1) starting from 1-tetralone is reported. The claimed identity of samoquasine A with perlolidine (4) has been discussed in the light of the present synthesis.

Keywords

thiourea - condensation - heterocycles - natural products - sulfur - dehydrogenations

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