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Synlett 2003(13): 2086-2088  
DOI: 10.1055/s-2003-42042
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Practical Parallel Synthesis of 2-Substituted Indolizines

Wenying Chai*, Annette Kwok, Victoria Wong, Nicholas I. Carruthers, Jiejun Wu
Johnson & Johnson Pharmaceutical Research and Development L.L.C, 3210 Merryfield Row, San Diego, California CA 92121, USA
Fax: +1(858)4502049; e-Mail: wchai@prdus.jnj.com;
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Publication History

Received 5 August 2003
Publication Date:
08 October 2003 (online)

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Abstract

A practical parallel synthesis of 2-substituted indolizines 4 via phase-separation techniques is reported. Their further transformation into indolizidines 5 is also described.

Key words

indolizine - Tschitschibabin indolizine synthesis - parallel synthesis - indolizidine - hydrogenation.