Download PDF
Planta Med 2003; 69(7): 675-677
DOI: 10.1055/s-2003-41118
Letter
© Georg Thieme Verlag Stuttgart · New York

Antibacterial New Clerodane Diterpenes from the Surface of Haplopappus foliosus

Alejandro Urzúa1 , René Torres2 , Leonora Mendoza3 , Franco Delle Monache4
  • 1Laboratory of Chemical Ecology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile
  • 2Department of Basic Chemistry, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile
  • 3Department of Chemistry of Materials, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile
  • 4Centro CNR dei Reccettori, Catholic University del Sacro Cuore, Rome, Italy
Further Information

Publication History

Received: September 12, 2002

Accepted: March 29, 2003

Publication Date:
04 August 2003 (online)

    Permissions and Reprints

Abstract

A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC. is reported. Purification of the two active fractions yielded 2-α-hydroxy-cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (1) and 2-α-acetoxy-cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (2), two new clerodane diterpenes.

References

  • 1 Farga C, Lastra J. Plantas medicinales de uso común en Chile. Vol. I Santiago de Chile; Soprami 1988: p. 11
    Google Scholar
  • 2 Urzúa A, Mendoza L. Antibacterial activity of the resinous exudates from Haplopappus uncinatus and Haplopappus foliosus .  Fitoterapia. 2001;  72 418-20
    CrossrefPubMedGoogle Scholar
  • 3 Tori M, Katto A, Sono M. Nine new clerodane diterpenoids from rhizomes of Solidago altissima .  Phytochemistry. 1999;  52 487-93
    CrossrefPubMedGoogle Scholar
  • 4 Avila D, Medina J D, Deeming A J. New clerodane type diterpenoid from Eperua leucantha .  J Nat Prod. 1992;  55 845-50
    CrossrefPubMedGoogle Scholar
  • 5 Rezende M C, Urzúa A, Bortoluzzi A J, Vásquez L. Variation of the antimicrobial activity of Pseudognaphalium vira vira (Asteraceae): isolation and X-ray structure of ent-3β-hydroxy-16-kauren-19-oic acid.  J Ethnopharmacol. 2000;  72 459-64
    CrossrefPubMedGoogle Scholar
  • 6 Wilkens M, Alarcón C, Urzúa A, Mendoza L. Characterization of the bactericidal activity of the natural diterpene kaurenoic acid.  Planta Med. 2002;  68 452-4
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Urzúa A, Rezende M C, Vásquez L, Mendoza L, Wilkens M, Tojo E. Antimicrobial study of the resinous exudate and diterpenoids isolated from Eupatorium salvia (Asteraceae).  J Ethnopharmacol. 1998;  62 251-4
    CrossrefPubMedGoogle Scholar
  • 8 Urzúa A, Andrade L, Jara F. Comparative leaf surface chemistry from Haplopappus foliosus and Haplopappus uncinatus .  Biochem Syst Ecol. 2000;  28 491
    PubMedGoogle Scholar
  • 9 Urzúa A, Modak B, Villarroel L, Torres R, Andrade L. Comparative flavonoid composition of the resinous exudates from Heliotropium Chenopodiaceum var. ericoideum and H. chenopodiaceum var. chenopodiaceum .  Biochem Syst Ecol. 1998;  26 127-30
    PubMedGoogle Scholar
  • 10 Mayr-Harting A, Hedges A, Berkeley R (eds.). Methods for studying bacteriocins. New York; Academic Press 1972: p. 74
    Google Scholar
  • 11 Ausubel F, Brent R, Kingston R E, Moore D D, Seidman J G. Short protocols in Molecular Biology. New York; John Wiley and Sons 1999: pp. 1-3
    Google Scholar
  • 12 Murray P, Baron E J, Pfaller M A, Tenover F C, Yolken R H. Manual of Clinical Microbiology. Washington DC; American Society for Microbiology 1999: p. 1.105
    Google Scholar
  • 13 Prescott L M, Harley P J, Klein D A. Microbiología. 4th Edn Mexico; McGraw-Hill Interamericana 1999: p. 760
    Google Scholar

Prof. Dr. René Torres

Department of Basic Chemistry

University of Santiago of Chile

Casilla 40

Correo 33

Santiago of Chile

Chile

Email: aurzuamoll44@yahoo.com

      >