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Synlett 2003(6): 0809-0812
DOI: 10.1055/s-2003-38726
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

New Polymer-Supported Allyloxycarbonyl (Alloc) and Propargyloxycarbonyl (Proc) Amino-Protecting Reagents

Rafael Chinchilla, David J. Dodsworth, Carmen Nájera*, José M. Soriano
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apartado 99, 03080 Alicante, Spain
Fax: +34(96)5903549; e-Mail: cnajera@ua.es;
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Publication History

Received 21 January 2003
Publication Date:
17 April 2003 (online)

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Abstract

New polymer-supported reagents, Alloc-P-OSu and Proc-P-OSu, have been prepared from a polymeric N-hydroxysuccinimide (P-HOSu), and used as solid-supported reagents for the allyloxycarbonyl (Alloc) and propargyloxycarbonyl (Proc) protection of the amino group. These new polymeric reagents are safe and stable, the residual P-HOSu generated after the protection reaction can be easily separated by simple filtration and reused.

Key words

amino acids - polymers - protecting reagents - solid-supported reagents

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Novabiochem (2002/3 catalogue: 5 g, 162 ).

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