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Planta Med 2002; 68(2): 167-169
DOI: 10.1055/s-2002-20245
Letter

© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial Activity of Uvaria klaineana

B. Akendengue1 , E. Ngou-Milama1 , F. Roblot2 , A. Laurens2 , R. Hocquemiller2 , Ph. Grellier3 , F. Frappier4
  • 1Département de Chimie-Biochimie, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon
  • 2Laboratoire de Pharmacognosie, UPRES-A 8076 CNRS, Faculté de Pharmacie, Châtenay-Malabry, France
  • 3Laboratoire de Biologie Parasitaire, Muséum National d'Histoire Naturelle, FR 63 CNRS, Paris, France
  • 4Laboratoire de Chimie des Substances Naturelles, Muséum National d'Histoire Naturelle, ESA 8041 CNRS, Paris, France
Further Information

Publication History

March 16, 2001

May 26, 2001

Publication Date:
22 February 2002 (online)

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Abstract

Crude extracts of Uvaria klaineana Engler and Diels (Annonaceae) stems showed in vitro activity against chloroquine-resistant K1 strain of Plasmodium falciparum. The most active extract was the basic dichloromethane extract containing crude alkaloids (IC50 = 3.55 μg/mL). The bioassay-guided fractionation of this extract led to the isolation of the major alkaloid crotsparine (1) which showed an antiplasmodial activity against the chloroquine-sensitive Thai strain of P. falciparum and the chloroquine-resistant K1 and FcB1 strains of P. falciparum. Two minor alkaloids were also identified as crotonosine (2) and zenkerine (3). Their structures were elucidated using 2D-NMR techniques.

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Alain Laurens

Laboratoire de Pharmacognosie

UPRES-A CNRS 8076 (BioCIS)

Faculté de Pharmacie

92296 Châtenay-Malabry

rance

Email: alain.laurens@cep.u-psud.fr

Fax: +33 146-835-399

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