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Semin Hear 2001; 22(4): 347-360
DOI: 10.1055/s-2001-19110
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Otoacoustic Emissions as a Window onto Prenatal Development and Sexual Differentiation

Dennis McFadden
  • Department of Psychology and Institute for Neuroscience, University of Texas, Austin, Texas
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Publication History

Publication Date:
18 December 2001 (online)

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ABSTRACT

Otoacoustic emissions (OAEs) and auditory evoked potentials (AEPs) exhibit sex differences, and these are present in infants and children as well as in adults. OAEs and AEPs are also different in several special populations of subjects. For females having opposite-sex cotwins (OSDZ females) and for homosexual and bisexual females, average OAE measures are shifted toward those of males. Certain AEP measures from homosexual and bisexual females also are masculinized. Certain AEP measures from homosexual males are hypermasculinized. These and other facts can be explained by assuming that these special populations received greater than normal exposures to androgens at some point(s) during development, possibly during prenatal development. The implication is that the auditory system may be capable of providing insights into the processes of human development and sexual differentiation.

KEYWORD

Homosexuality - auditory system - masculinization - hypermasculinization - androgens

REFERENCES

  • 1 McFadden D. Sex differences in the auditory system.  Dev Neuropsych . 1998;  14 261-298
    PubMedGoogle Scholar
  • 2 Davis H. An active process in cochlear mechanics.  Hear Res . 1983;  9 79-90
    CrossrefPubMedGoogle Scholar
  • 3 McFadden D, Mishra R. On the relation between hearing sensitivity and otoacoustic emissions.  Hear Res . 1993;  71 208-213
    CrossrefPubMedGoogle Scholar
  • 4 McFadden D, Pasanen E. Spontaneous otoacoustic emissions in heterosexuals, homosexuals, and bisexuals.  J Acoust Soc Am . 1999;  105 2403-2413
    CrossrefPubMedGoogle Scholar
  • 5 Shera C, Guinan Jr J. Evoked otoacoustic emissions arise by two fundamentally different mechanisms: a taxonomy for mammalian OAEs.  J Acoust Soc Am . 1999;  105 782-798
    CrossrefPubMedGoogle Scholar
  • 6 Whitehead M. Slow variations of the amplitude and frequency of spontaneous otoacoustic emissions.  Hear Res . 1991;  53 269-280
    CrossrefPubMedGoogle Scholar
  • 7 Pasanen E, McFadden D. An automated procedure for detection and measurement of spontaneous otoacoustic emissions.  J Acoust Soc Am . 2000;  108 1105-1116
    CrossrefPubMedGoogle Scholar
  • 8 Hall III J. Handbook of Auditory Evoked Responses Boston: Allyn & Bacon; 1992
  • 9 McFadden D, Champlin C. Comparison of auditory evoked potentials in heterosexual, homosexual, and bisexual males and females.  J Assoc Res Otolaryngol . 2000;  1 89-99
    PubMedGoogle Scholar
  • 10 Chiarenza G, D'Ambrosio G, Cazzullo A. Sex and ear differences of brain-stem acoustic evoked potentials in a sample of normal full-term newborns. Normative study.  Electroencephalogr Clin Neurophysiol . 1988;  71 357-366
    PubMedGoogle Scholar
  • 11 McFadden D, Loehlin J. On the heritability of spontaneous otoacoustic emissions: a twins study.  Hear Res . 1995;  85 181-198
    CrossrefPubMedGoogle Scholar
  • 12 McFadden D, Loehlin J, Pasanen E. Additional findings on heritability and prenatal masculinization of cochlear mechanisms: click-evoked otoacoustic emissions.  Hear Res . 1996;  97 102-119
    CrossrefPubMedGoogle Scholar
  • 13 McFadden D. A masculinizing effect on the auditory systems of human females having male co-twins.  Proc Natl Acad Sci U S A . 1993;  90 11900-11904
    PubMedGoogle Scholar
  • 14 Bilger R, Matthies M, Hammel D, Demorest M. Genetic implications of gender differences in the prevalence of spontaneous otoacoustic emissions.  J Speech Hear Res . 1990;  33 418-432
    PubMedGoogle Scholar
  • 15 Talmadge C, Long G, Murphy W, Tubis A. New off-line method for detecting spontaneous otoacoustic emissions in human subjects.  Hear Res . 1993;  71 170-182
    CrossrefPubMedGoogle Scholar
  • 16 McFadden D, Pasanen E. Comparison of the auditory systems of heterosexuals and homosexuals: click-evoked otoacoustic emissions.  Proc Natl Acad Sci U S A . 1998;  95 2709-2713
    CrossrefPubMedGoogle Scholar
  • 17 Cohen J. A power primer.  Psychol Bull . 1992;  112 155-159
    CrossrefPubMedGoogle Scholar
  • 18 Franklin D, McCoy M, Martin G, Lonsbury-Martin B. Test/retest reliability of distortion-product and transiently evoked otoacoustic emissions.  Ear Hear . 1992;  13 417-429
    PubMedGoogle Scholar
  • 19 Burns E, Campbell S, Arehart K, Keefe D. Long-term stability of spontaneous otoacoustic emissions.  Abst Assoc Res Otolaryngol . 1993;  16 98
    PubMedGoogle Scholar
  • 20 Burns E, Campbell S, Arehart K. Longitudinal measurements of spontaneous otoacoustic emissions in infants.  J Acoust Soc Am . 1994;  95 385-394
    PubMedGoogle Scholar
  • 21 Prieve B, Gorga M, Schmidt A. Analysis of transient-evoked otoacoustic emissions in normal-hearing and hearing-impaired ears.  J Acoust Soc Am . 1993;  93 3308-3319
    PubMedGoogle Scholar
  • 22 Norton S. The effects of being a newborn on otoacoustic emissions.  J Acoust Soc Am . 1992 (Suppl 1);  91 2409
    PubMedGoogle Scholar
  • 23 McFadden D. Masculinization effects in the auditory system.  Arch Sex Behav. (in press); 
    PubMedGoogle Scholar
  • 24 Jerger J, Johnson K. Interactions of age, gender, and sensorineural hearing loss on ABR latency.  Ear Hear . 1988;  9 168-176
    CrossrefPubMedGoogle Scholar
  • 25 Bancroft J, Sherwin B, Alexander G, Davidson D, Walker A. Oral contraceptives, androgens, and the sexuality of young women: II. The role of androgens.  Arch Sex Behav . 1991;  20 121-135
    CrossrefPubMedGoogle Scholar
  • 26 McFadden D. Masculinizing effects on otoacoustic emissions and auditory evoked potentials in women using oral contraceptives.  Hear Res . 2000;  142 22-33
    PubMedGoogle Scholar
  • 27 Bell A. Circadian and menstrual rhythms in frequency variations of spontaneous otoacoustic emissions from human ears.  Hear Res . 1992;  58 91-100
    CrossrefPubMedGoogle Scholar
  • 28 Haggerty H, Lusted H, Morton S. Statistical quantification of 24-hour and monthly variabilities of spontaneous otoacoustic emission frequency in humans.  Hear Res . 1993;  70 31-49
    CrossrefPubMedGoogle Scholar
  • 29 Elkind-Hirsch K, Stoner W, Stach B, Jerger J. Estrogen influences auditory brainstem responses during the normal menstrual cycle.  Hear Res . 1992;  60 143-148
    CrossrefPubMedGoogle Scholar
  • 30 Elkind-Hirsch K, Wallace E, Malinak L, Jerger J. Sex hormones regulate ABR latency.  Otolaryngol Head Neck Surg . 1994;  110 46-52
    PubMedGoogle Scholar
  • 31 Burns E, Arehart K, Campbell S. Prevalence of spontaneous otoacoustic emissions in neonates.  J Acoust Soc Am . 1992;  91 1571-1575
    PubMedGoogle Scholar
  • 32 Sininger Y, Cone-Wesson B, Abdala C. Gender distinctions and lateral asymmetry in the low-level auditory brainstem response of the human neonate.  Hear Res . 1998;  126 58-66
    CrossrefPubMedGoogle Scholar
  • 33 Lauter J, Karzon R. Individual differences in auditory electric responses: comparisons of between-subject and within-subject variability. IV. Latency-variability comparisons in early, middle, and late responses.  Scand Audiol . 1990;  19 175-182
    CrossrefPubMedGoogle Scholar
  • 34 Lauter J, Karzon R. Individual differences in auditory electric responses: comparisons of between-subject and within-subject variability. V. Amplitude-variability comparisons in early, middle, and late responses.  Scand Audiol . 1990;  19 201-206
    CrossrefPubMedGoogle Scholar
  • 35 Arnold A, Breedlove S. Organizational and activational effects of sex steroids on brain and behavior: a reanalysis.  Horm Behav . 1985;  19 469-498
    CrossrefPubMedGoogle Scholar
  • 36 Smail P, Reyes F, Winter J, Faiman C. The fetal hormonal environment and its effect on the morphogenesis of the genital system. In: Kogan S, Hafez E, eds. Pediatric Andrology The Hague: Martinus Nijhoff 1981: 9-19
    Google Scholar
  • 37 Clark M, Galef Jr B. Effects of intrauterine position on the behavior and genital morphology of litter-bearing rodents.  Dev Neuropsych . 1998;  14 197-211
    PubMedGoogle Scholar
  • 38 vom Saal F. Sexual differentiation in litter-bearing mammals: influence of sex of adjacent fetuses in utero.  J Anim Sci . 1989;  67 1824-1840
    PubMedGoogle Scholar
  • 39 Miller E. Prenatal sex hormone transfer: a reason to study opposite-sex twins.  Person Indiv Diff . 1994;  17 511-529
    PubMedGoogle Scholar
  • 40 Loehlin J, Martin N. A comparison of adult female twins from opposite-sex and same-sex pairs on variables related to reproduction.  Behav Genet . 1998;  28 21-27
    CrossrefPubMedGoogle Scholar
  • 41 McFadden D, Pasanen E, Callaway N. Changes in otoacoustic emissions in a transsexual male during treatment with estrogen.  J Acoust Soc Am . 1998;  104 1555-1558
    CrossrefPubMedGoogle Scholar
  • 42 Kemp D. Evidence of mechanical nonlinearity and frequency selective wave amplification in the cochlea.  Arch Otol Rhinol Laryngol . 1979;  224 37-45
    PubMedGoogle Scholar
  • 43 Probst R, Lonsbury-Martin B, Martin G. A review of otoacoustic emissions.  J Acoust Soc Am . 1991;  89 2027-2067
    PubMedGoogle Scholar
  • 44 Kemp D. Stimulated acoustic emissions from within the human auditory system.  J Acoust Soc Am . 1978;  64 1386-1391
    CrossrefPubMedGoogle Scholar
  • 45 McFadden D. A speculation about the parallel ear asymmetries and sex differences in hearing sensitivity and otoacoustic emissions.  Hear Res . 1993;  68 143-151
    CrossrefPubMedGoogle Scholar
  • 46 Whitehead M, Kamal N, Lonsbury-Martin B, Martin G. Spontaneous otoacoustic emissions in different racial groups.  Scand Audiol . 1993;  23 3-10
    PubMedGoogle Scholar
  • 47 McFadden D. Tinnitus: Facts, Theories, and Treatments.  Washington, DC: National Academy Press; 1982
    Google Scholar
      >