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Synlett 2001; 2001(12): 1968-1970
DOI: 10.1055/s-2001-18760
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Preparation of Secondary and Tertiary Amides under Neutral Conditions by Photochemical Acylation of Amines

Céline Helgen* , Christian G. Bochet
  • *Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland; Fax: + 41(22)3287396; E-mail: Christian.Bochet@chiorg.unige.ch
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Publication History

Publication Date:
04 December 2001 (online)

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The smooth and neutral acylation of amines to form amides by photoactivation of N-acyl-5,7-dinitroindolines is described. An improved acylation of nitroindolines allows the convenient preparation of N-acylnitroindolines. This reaction makes possible the recycling of the nitroindoline released during the photoactivation.

acylations - amides - indoles - photochemistry - protecting groups

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