Osteoblastic Proliferation Stimulating Activity of Psoralea corylifolia Extracts and Two of its Flavonoids

Abstract

Psoralea corylifolia L. fruit extracts exhibited osteoblastic proliferation stimulating activity in UMR106 cell line cultured in vitro. The flavonoids of corylin and bavachin were isolated and identified as active principles by activity-guided fractionation. The results suggested that Psoralea corylifolia L. fruit extracts and corylin and bavachin might stimulate bone formation or have potential activity against osteoporosis.

References

• 1 Lu J, Lin D, Li Z. Study of chemical constituents and pharmacological effect of Psoralea corylifolia .  Chinese Journal of Shenyang Pharmaceutical University. 1996;  13 220-3
• 2 Zhang R, Shi F, Pang S Z. Study on the effect of Psoralea corylifolia on isolated osteoclasts.  Chinese Journal of Modern Dentistry. 1995;  9 136-8
• 3 Miura H, Nishida H, Linuma M. Effect of crude fraction of Psoralea corylifolia seed extract on bone calcification.  Planta Medica. 1996;  62 150-3
• 4 Farley J R, Wergedal J E, Baylink D J. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells.  Science. 1983;  222 330-2
• 5 Peng G, Guan P, Li H, Yuan Y. Study on chemical constituents of Psoralea corylifolia .  Chinese Traditional and Herbal Drugs. 1996;  19 563-5
• 6 Bhalla V K, Ramdas U, Dev S. Some new flavonoids from Psoralea corylifolia .  Tetrahedron Letters. 1968;  20 2401-6
• 7 Wang D, Li F, Gao X, Jiang Z. Effect of Drynaria baronii rhizome extracts on cell proliferation in osteoblast-like UMR106 cells. Pharmaceutical Biology in press