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Synlett 2001; 2001(9): 1379-1382
DOI: 10.1055/s-2001-16789
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Novel Chiral Glycerol Analogues Building Blocks. Application to the Synthesis of Bioactive Glycoglycerolipid Analogues

Patrizia Ferraboschi* , Diego Colombo, Federica Compostella, Shahrzad Reza-Elahi
  • *Dipartimento di Chimica e Biochimica Medica-Via Saldini, 50-20133-Milan, Italy; Fax + 39-2-58356040; E-mail: Patrizia.Ferraboschi@unimi.it
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Publication Date:
28 August 2001 (online)

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Monoacylglycosylglycerols show anti-tumor promoting effects: in order to study the role of the ester function we have prepared by simple methods (R)-1-O-benzyl-1,2-decandiolk (R)-3-O-benzyl-1-O-hexyl-su-glycerol, and (R)-1-O-benzyl-5-oxo-1,2-decandiol; these optically active compounds are building blocks for the synthesis of monohexanoylglycosylglycerol isosters.

glycolipids - antitumor agents - isosters - building blocks - synthons

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