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Synlett 2001; 2001(9): 1411-1414
DOI: 10.1055/s-2001-16776
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Synthesis of 2-Nitroalcohols by Regioselective Ring Opening of Epoxides with MgSO4/MeOH/NaNO2 System: A Short Synthesis of Immunosuppressive Agent FTY-720

Biswajit Kalita* , Nabin C. Barua, Maitreyee (Sarma) Bezbarua, Ghanashyam Bez
  • *Organic Chemistry Division (Natural Products Chemistry), Regional Laboratory, Jorhat-785006, Assam, India; Fax + 91(0376)37 00 11; E-mail: ncbarua@hotmail.com
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Publication History

Publication Date:
28 August 2001 (online)

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It has been demonstrated that a variety of epoxides can easily be opened with a system consisting of MgSO4/MeOH/NaNO2 giving the corresponding 2-nitroalcohols in excellent yields. This strategy has been applied to achieve a short synthesis of Immunosuppressive Agent FTY-720.

2-nitroalcohols - nitroaliphatics - epoxides - immunosuppressive agent FTY-720 - ring opening

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