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Synlett 2001; 2001(7): 1101-1104
DOI: 10.1055/s-2001-15164
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Parallel Synthesis of Oligosaccharide Conjugated Enediynes onto Silyl-linked Solid-Support

Akihisa Matsuda* , Takayuki Doi, Hiroshi Tanaka, Takashi Takahashi
  • *Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan; Fax + 81-3-57 34-28 84; E-mail: ttakashi@o.cc.titech.ac.jp
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Publication Date:
31 December 2001 (online)

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A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.

solid-phase synthesis - oligosaccharides - coupling - thiols

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