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Synlett 2001; 2001(7): 1109-1112
DOI: 10.1055/s-2001-15146
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Diastereoselective, One-Pot Synthesis of γ-Amino Alcohols from Ketimines

Siem J. Veenstra* , Sape S. Kinderman
  • *Novartis Pharma AG, Klybeckstrasse 141, 4057 Basel, Switzerland; Fax + 41 61 6 96 86 76; E-mail: siem.veenstra@pharma.novartis.com
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Publication History

Publication Date:
31 December 2001 (online)

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Deprotonation of ketimines with lithium diisopropyl amide, followed by reaction with aldehydes and subsequent reduction with aluminium hydrides gave γ-amino alcohols with moderate to good syn selectivity. The scope and limitations of this preparative method are reported.

diastereoselectivity - reduction - amino alcohols - ketimines - amide bases

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