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Synlett 2001; 2001(2): 0263-0265
DOI: 10.1055/s-2001-10787
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A Novel Method for Direct Construction of Indole Skeletons by Intramolecular Carbopalladation of Allenes Followed by Nucleophilic Substitution

Kunio Hiroi* , Yuko Hiratsuka, Kazuhiro Watanabe, Ikuko Abe, Fumiko Kato, Mayumi Hiroi
  • *Department of Synthetic Organic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan; Fax +81-22-275-2013; E-mail: khiroi§tohoku-pharm.ac.jp
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Publication History

Publication Date:
31 December 2001 (online)

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Upon treatment with a palladium catalyst, (o-iodoanilinoalkyl)allene compounds undergo intramolecular carbopalladation of allenes followed by intramolecular amination of π-allylpalladium complexes to afford indole derivatives in fairly good yields.

allenes - arylations - indoles - palladium - substitutions

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