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Synlett 2001; 2001(2): 0230-0231
DOI: 10.1055/s-2001-10781
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A One-Pot Method for the Efficient Preparation of Aromatic Nitriles from Aldehydes Using Ammonia, Magnesium Sulfate, and Manganese Dioxide

Gaifa Lai* , Nana K. Bhamare, Wayne K. Anderson
  • *Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, NY 14260, USA; Fax +1-732-422-0156; E-mail: glai§pharmacop.com
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Publication Date:
31 December 2001 (online)

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A one-pot and efficient preparation of aromatic nitriles from the corresponding aldehydes was accomplished by treatment with 2 M ammonia solution in 2-propanol, magnesium sulfate, and manganese dioxide in THF at room temperature. This method was found to be compatible with a variety of functionalities such as hydroxyl, ester, and amide.

aromatic nitriles - aldehydes - manganese dioxide

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