Coumarins and Antiplatelet Constituents from the Root Bark of Zanthoxylum schinifolium

Abstract

Further study on the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallylol (4), hydroxyepoxycollinin II (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.

Key words

Zanthoxylum schinifolium - Rutaceae - root bark - coumarin - terpenyl-coumarins - alkaloids - furoquinolines - antiplatelet aggregation activity - anti-HBV DNA replication

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