Download PDF
Synlett 2000; 2000(5): 0603-0606
DOI: 10.1055/s-2000-6631
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Solid-Phase Synthesis of 1-Chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI) and a Polyamide Conjugate

Guofeng Jia* , Hirokazu Iida, J. William Lown
  • *Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2; Fax + 1 (780) 492-8231; E-mail: annabelle.wiseman@ualberta.ca
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Solid-phase intramolecular aryl radical cyclization onto a vinyl chloride allows the synthesis of 1-chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI), a structure related to the pharmacophores of CC-1065 and duocarmycin SA. A representative unsymmetrical bis-polyamide conjugate was also synthesized.

solid-phase synthesis - radical cyclization - seco-CBI - polyamides - conjugate

      >