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Synthesis 2000; 2000(4): 507-509
DOI: 10.1055/s-2000-6367
short paper
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A Practical Large-Scale Synthesis of 3-Carbomethoxy-3-sulfolene

John Leonard* , Andrew B. Hague, Martin F. Jones, Richard A. Ward
  • *Chemistry Department, University of Salford, Salford M5 4WT, UK; E-mail: j.leonard@salford.ac.uk
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Publication Date:
31 December 2000 (online)

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A simple, efficient one-flask procedure for the large-scale preparation of 3-carbomethoxy-3-sulfolene from trimethylphosphonoacetate is described. The procedure incorporates a cheap and simple sulfide to sulfone oxidation using Oxone®. No chromatography or intermediate purification steps are involved and the product is isolated by crystallisation.

3-carboxymethoxy-3-sulfolene - 2,5-dihydroxy-1,4-dithiane - Oxone

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