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Synthesis 2000; 2000(3): 435-441
DOI: 10.1055/s-2000-6335
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An Expedient Synthesis of Novel [1,2,4]Triazolo[3,2-d][1,5]Benzothiazepine Derivatives

Xianjun Liu* , Quanrui Wang, Yi Liu, Yubo Fan, Zongbiao Ding
  • *Department of Chemistry, Fudan University, 200433 Shanghai, P. R. China; Fax +86 (21) 65 64 17 40; E-mail: qrwangb@online.sh.cn
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Publication Date:
31 December 2000 (online)

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The synthesis of a series of unprecedented tricyclic heterocycles, 1,2,4-triazolo[3,2-d][1,5]benzothiazepine 6-oxides (5a-i), was accomplished via cycloaddition of the allene-like cations 3, derived from thiochroman-4-one arylhydrazones, to the triple bond of nitriles and ensuing ring expansion annulation. The structure of one product (5h) has been unambiguously determined by X-ray diffraction analysis.

allene-like cations - cycloaddition - nitriles - ring expansion - 1,2,4-triazolo[3,2-d][1,5]benzothiazepine 6-oxides

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