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Synthesis 2000; 2000(7): 941-948
DOI: 10.1055/s-2000-6307
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Aminomethylation of Functionalized Organozinc Reagents and Grignard Reagents Using Immonium Trifluoroacetates

Nicolas Millot* , Claudia Piazza, Salvatore Avolio, Paul Knochel
  • *Institut für Organische Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5 - 13, D-81377 München, Germany; Fax +49(89)21807680; E-mail: Paul.Knochel@cup.uni-muenchen.de
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Publication Date:
31 December 2000 (online)

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New immonium trifluoroacetates 1 and 2 react readily with functionalized organozinc or magnesium reagents leading to the corresponding aminomethylated products of type 5 and 7. The resulting bis-allylamines were deallylated leading to primary amines.

organometallic reagents - zinc - magnesium - aminomethylation - primary amines - deprotection

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