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Synthesis 1999; 1999(3): 467-470
DOI: 10.1055/s-1999-3422
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An Innovative Approach to the Synthesis of Complex Biaryls from Suitably Functionalized 2H-Pyran-2-ones Through Ring Transformation Reactions

Vishnu Ji Ram* , Atul Goel
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India; E-mail: root@cscdri.ren.nic.in
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Publication Date:
31 December 1999 (online)

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An innovative route for the synthesis of biaryls 3a-i, 5a-h has been developed through carbanion-induced ring transformation reactions of 6-aryl-3-methoxycarbonyl-4-methylthio-2H-pyran-2-one (1).

2H-pyran-2-one - cyclic ketone - biaryl - tetrahydroisoquinoline - ring-transformation reaction

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