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Synlett 1999; 1999(12): 1984-1986
DOI: 10.1055/s-1999-2999
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Practical and Efficient Chlorination of Deactivated Anilines and Anilides with NCS in 2-Propanol

Atsuhiko Zanka* , Ariyoshi Kubota
  • *Technological Development Laboratories, Fujisawa Pharmaceutical Co. Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka, 532-8514, Japan; Fax + 81 6 63 90 11 83; E-mail: atsuhiko_zanka@po.fujisawa.co.jp
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Publication Date:
31 December 1999 (online)

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Deactivated anilines and anilides were efficiently monochlorinated with NCS in 2-propanol. The described method was applicable to a large scale synthesis.

aniline - anilide - chlorination - 2-propyl hypochlorite - N-chlorosuccinimide

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