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Synlett 1999; 1999(12): 1948-1950
DOI: 10.1055/s-1999-2985
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Efficient Syntheses of Cyclopropylacetylene, a Crucial Synthetic Intermediate for Efavirenz (DMP-266)

Shaun E. Schmidt* , Ralph N. Salvatore, Kyung Woon Jung, Taesoo Kwon
  • *Department of Chemistry (CHE 305), University of South Florida and Drug Discovery Program, H. Lee Moffitt Cancer Center & Research Institute, 4202 E. Fowler Avenue, Tampa, Florida 33620-5250, USA; Fax + 1(8 13)9 74-17 33; E-mail: kjung@chuma.cas.usf.edu
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Publication Date:
31 December 1999 (online)

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Efficient syntheses of cyclopropylacetylene were achieved from cyclopropyl methyl ketone. Different reaction pathways were investigated to avoid the concomitant formation of any side products.

cyclopropylacetylene - chlorination - dehydrochlorination

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