Download PDF
Synlett 1999; 1999(12): 1923-1924
DOI: 10.1055/s-1999-2978
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil

Mark J. Coleman* , Michael D. Goodyear, David W. S. Latham, Andrew J. Whitehead
  • *Chemical Development Division, Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

A general method has been devised for the one step preparation of N-acylamino acid esters of type 7 from the corresponding α-amino acids in high yield under mild conditions and a probable mechanism is proposed.

acylation - esterification - amino acids

      >