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Synlett 1999; 1999(11): 1781-1783
DOI: 10.1055/s-1999-2946
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Selective Monoalkylation of Ammonia: A High Throughput Synthesis of Primary Amines

Sukanta Bhattacharyya* , Kurt A. Neidigh, Mitchell A. Avery, John S. Williamson
  • *Department of Chemistry, The University of Mississippi, University, MS 38677, USA
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Publication History

Publication Date:
31 December 1999 (online)

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Primary amines are obtained in good to excellent yields by highly selective monoalkylation of ammonia with alkyl and aryl ketones using titanium(IV) isopropoxide and sodium borohydride.

primary amines - reductive amination - titanium(IV) isopropoxide

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