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Synlett 1999; 1999(10): 1642-1644
DOI: 10.1055/s-1999-2905
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Rapid Synthesis of Oxazoles under Microwave Conditions

Christopher T. Brain* , Jane M. Paul
  • *Novartis Institute for Medical Sciences, 5 Gower Place, London, WC1E 6BN, UK; Fax + 44(0)17 13 87 41 16; E-mail: christopher.brain@pharma.novartis.com
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Publication Date:
31 December 1999 (online)

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A new and efficient variation of the Robinson-Gabriel oxazole synthesis is described. Oxazoles were prepared by cyclodehydration of 2-acylamino carbonyl compounds with Burgess reagent under monomode microwave irradiation.

oxazoles - cyclization - microwaves

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