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Synlett 1999; 1999(9): 1477-1479
DOI: 10.1055/s-1999-2870
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Efficient Generation of Trifluoroacetaldehyde and Successive Reaction with Imines Affording β-Hydroxy-β-trifluoromethyl Ketones

Kazumasa Funabiki* , Kei Matsunaga, Masaki Matsui, Katsuyoshi Shibata
  • *Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu, 501-1193, Japan; Fax + 81-58-2 30-18 93; E-mail: kfunabik@apchem.gifu-u.ac.jp
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Publication Date:
31 December 1999 (online)

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The reaction of trifluoroacetaldehyde ethyl hemiacetal or hydrate with an equimolar amount of imine in hexane at reflux temperature for 1 h gave the corresponding β-hydroxy-β-trifluoromethyl ketones in good to excellent yields.

trifluoroacetaldehyde - hemiacetal - hydrate - imine - β-hydroxy-β-trifluoromethyl ketones

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