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Synlett 1999; 1999(3): 317-318
DOI: 10.1055/s-1999-2616
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A Facile Regio- and Stereocontrolled Synthesis of (E)-Disubstituted Vinyl Sulfones via Transformation of Alkenylzirconocenes with Sulfonyl Chlorides

De-Hui Duan* , Xian Huang
  • *Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou, Zhejiang, P.R. China, 310028; Fax 86 5 71 8 80 70 77; E-mail: huangx@public.hz.zj.cn
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Publication History

Publication Date:
31 December 1999 (online)

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Alkenylzirconium reagents, readily obtained by hydrozirconation of terminal alkynes, can smoothly react with sulfonyl chlorides to afford (E)-disubstituted vinyl sulfones in moderate to good yields. Some γ-functionalized vinyl sulfones can be also conveniently synthesized.

vinyl sulfone - hydrozirconation - alkenylzirconocene - sulfonyl chloride - γ-functionalized vinyl sulfone

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