Download PDF
Synlett 1998; 1998(10): 1099-1101
DOI: 10.1055/s-1998-1884
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Efficient Asymmetric Synthesis of (S)-2-Methylasparagine

Yutaka Aoyagi* , Robert M. Williams
  • *Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

(S)-2-methylasparagine was prepared from both (5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one ((-)-1) and its antipode ((+)-1) via stereoselective glycine enolate alkylation as a key step.

chiral template - asymmetric synthesis - (S)-2-methylasparagine - quaternary amino acid - stereoselective alkylation

      >