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Synlett 1998; 1998(10): 1077-1078
DOI: 10.1055/s-1998-1879
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An Efficient Synthesis of 2-(Methylaminomethyl)-4,5-Dialkyl-1H-Imidazoles

Valérie A. Reader*
  • *Department of Medicinal Chemistry, Research and Development Division, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406-0939, USA
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Publication History

Publication Date:
31 December 2000 (online)

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A mild and convenient synthesis of 2-(methylaminomethyl)-4,5-dialkyl-1H-imidazoles is described. The procedure was used in the preparation of 2-(methylaminomethyl)-4,5,6,7-tetrahydro-1H-benzimidazole 1 and 2-(methylaminomethyl)-4,5-dimethyl-1H-imidazole 2.

imidazole synthesis - methylthioimidate - 2-(methylaminomethyl)-4,5-dialkyl-1H-imidazoles

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