Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1998; 1998(10): 1159-1161
DOI: 10.1055/s-1998-1857
DOI: 10.1055/s-1998-1857
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
An Efficient Chloro-deamination Procedure, Application to the Synthesis of Advanced Vancomycin C-O-D-O-E Ring
Further Information
Publication History
Publication Date:
31 December 2000 (online)
An efficient chloro-deamination procedure was developed and a remarkable deuterium isotope effect indicating a radical mechanism was documented. Key to the success was the co-existence of a reductant (CuCl) and a ligand transfer agent (CuCl2) in the reaction medium employing CD3CN as co-solvent of CCl4. The procedure was applied to the synthesis of advanced vancomycin models.
Sandmeyer reaction - nitro - diazonium salt - vancomycin - kinetic isotope effect