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Synlett 1998; 1998(8): 906-908
DOI: 10.1055/s-1998-1806
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Immobilizations of Nucleophiles on Polystyrene Supports

Wolfgang K.-D. Brill* , Erika Schmidt, Ruben A. Tommasi
  • *Combinatorial Chemistry, Novartis Pharma AG, S-507.3.12, CH-4002 Basle; Fax + 41 61 324 42 36; E-mail: wolfgang_k-d.brill@pharma.novartis.com
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Publication History

Publication Date:
31 December 2000 (online)

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Some "benzhydrol and benzhydrylamine" resins were used to immobilize a variety of nucleophiles on a polymeric support. Immobilization of these nucleophiles under basic conditions gave better results, than under acidic conditions, due to less destruction of the resin.

polystyrene Support - linker trifluoroacetates - nucleophiles - displacement

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