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Synlett 1998; 1998(7): 718-720
DOI: 10.1055/s-1998-1764
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Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction

C. Oliver Kappe* , S. Fabio Falsone
  • *Institute of Organic Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria; Fax +43 316 3809840; E-mail: kappeco@balu.kfunigraz.ac.at
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Publication History

Publication Date:
31 December 2000 (online)

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Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.

Biginelli reaction - dihydropyrimidines - N-acyliminium ions - polyphospate ester - calcium channel modulators

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