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Synlett 1998; 1998(7): 762-764
DOI: 10.1055/s-1998-1757
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Direct Alkylation of Pyridazines and Related Compounds by Organolithium Reagents

Vittorio Dal Piaz* , Antonella Capperucci
  • *Dipartimento di Scienze Farmaceutiche, Via G. Capponi, 9 - 50121 Firenze, Italy; Fax +39-55-24 07 76; E-mail: vdp@farmfi.scifarm.unifi.it
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Publication History

Publication Date:
31 December 2000 (online)

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Reaction of chloropyridazines with lithium reagents afforded the corresponding 4(5)-alkylated 1,2-diazines, while treatment of 3(2H)-pyridazinones gave predominantly 4-alkylated-4,5-dihydro compounds.

pyridazines - 3(2H)-pyridazinones - organolithium reagents - alkylation

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