Download PDF
Synlett 1998; 1998(5): 479-482
DOI: 10.1055/s-1998-1717
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile Access to Aryl α-Sialosides: the Combination of a Volatile Amine Base and Acetonitrile in Glycosidation of Sialosyl Chlorides

Atsuhito Kuboki* , Takahiro Sekiguchi, Takeshi Sugai, Hiromichi Ohta
  • *Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan; Fax 81 45 563 5967; E-mail: sugai@chem.keio.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

We have succeeded in achieving a facile access to 4-nitrophenyl and 4-methylumbelliferyl-α-sialosides. To sialosyl chlorides which are fully protected with acetyl groups as glycosyl donors, the action of phenols with diisopropylethylamine in acetonitrile brought about high yield as well as facile product isolation.

aryl α-sialoside - glycosidation - diisopropylethylamine - sialic acid - KDN

      >